Personal profile
Author IDs
Scopus Author ID: 57211527103
Impact
Key information
Selected Publications (Last 5 Years)
1. X. Li*, Z. Ouyang, L. Hetjens, M. Ni, K. Lin, Y. Hu, X. Shi*, A. Pich*. Functional dendrimer nanogels for DNA delivery and gene therapy of tumors. Angew. Chem. Int. Ed. 2025, 64(30), e202505669.
2. X. Li, Y. Hu, X. Zhang*, X. Shi, W.J. Parak*, A. Pich*. Transvascular transport of nanocarriers for tumor delivery. Nat. Commun. 2024, 15(1), 8172.
3. X. Li, W. Zhang, H. Li, Q. Shuai, X. Zhang*, A. Pich*. Sprayed aqueous microdroplets for spontaneous synthesis of functional microgels. Angew. Chem. Int. Ed. 2025, 64(8), e202420926.
4. X. Li, Y. Lu, L. Kong, X. Shi*, A. Pich*. Leukocyte-nanomedicine system for targeted delivery and precise theragnostics. Chem 2022, 8(10), 2591.
5. X. Li, H. Sun, H. Li, C. Hu, Y. Luo*, X. Shi*, A. Pich*. Multi-responsive biodegradable cationic nanogels for highly efficient treatment of tumors. Adv. Funct. Mater. 2021, 31(26), 2100227.
6. X. Li, Y. Lu, Y. Hu*. A wireless and battery-free DNA hydrogel biosensor for wound infection monitoring. Matter 2022, 5(8), 2473.
7. X. Li, H. Li, C. Zhang, A. Pich*, L. Xing*, X. Shi*. Intelligent nanogels with self-adaptive responsiveness for improved tumor drug delivery and augmented chemotherapy. Bioact. Mater. 2021, 6(10), 3473.
8. Y. Shen, X. Li*, J. Wu, Y. Ma, S. Borchmann, Z. Cheng, Y. Wang, Y. Zhao, J. Song, B. Luo, X. Liu*, Y. Teng*, Z. Shi*. Bispecific nanosystems enable multieffector immune cell retargeting for hematologic malignancy therapy. Adv. Sci. 2025, 12(39), e09103.
9. X. Li, S. Lu, Z. Xiong, Y. Hu, D. Ma, W. Lou, C. Peng*, M. Shen*, X. Shi*. Light-addressable nanoclusters of ultrasmall iron oxide nanoparticles for enhanced and dynamic magnetic resonance imaging of arthritis. Adv. Sci. 2019, 6(19), 1901800.
10. L. Gao, L. Feng, D.F. Sauer, M. Wittwer, Y. Hu*, J. Schiffels*, X. Li*. Engineered living hydrogels for robust biocatalysis in pure organic solvents. Cell Rep. Phys. Sci. 2022, 3(10), 101054.
Biography
Dr. Xin Li is a Research Assistant Professor at Department of Biomedical Engineering, City University of Hong Kong. He received his PhD from RWTH Aachen University (Germany) under the supervision of Prof. Andrij Pich (Lichtenberg Professor). Subsequently, he worked as a Research Assistant at DWI-Leibniz-Institute for Interactive Materials (Germany), a Postdoctoral Fellow at Hong Kong University of Science and Technology (working with Prof. Ben Zhong Tang, CAS Academician), and a Research Associate at Chinese University of Hong Kong, respectively. His research focuses on developing green chemistry and synthetic biology strategies for large-scale production of smart microgels, investigating the mechanisms of microgel systems in efficient biocatalysis and biomedical applications, advancing clinically translatable nanomedicine for precision disease theranostics.
To date, he has published 80+ research articles/book chapters (Citation: 3000+, H-index: 34), 100+ patents, and 20+ international/national awards.
Editor or Editorial Membership
2023 - Now, Reginal Editor, Recent Patents on Nanotechnology (SCIE)
2026 - Now, Editorial Board Member, Letters in Drug Design & Discovery (SCIE)
2023 - Now, Editorial Board Member/Guest Editor, Journal of Pharmaceutical Analysis (SCIE)
2025 - Now, Early Career Editorial Board Member, International Journal of Molecular Sciences (SCIE)
2023 - Now, Youth Editorial Board Member, Nano Materials Science (SCIE)
2023 - Now, Youth Editorial Board Member, Asian Journal of Pharmaceutical Sciences (SCIE)
2023 - Now, Youth Editorial Board Member, View (SCIE)
2025, Guest Editor, International Journal of Nanomedicine (SCIE)
2023, Guest Editor, Pharmaceutics (SCIE)
Membership of Professional Bodies
2025, Member, The Hong Kong Research Grants Council Research Fellow Alliance (HKRFA)
2025, Member of Organizing Committee, 2025 Academic Forum on Tissue Engineering and Biomaterials (AFTEB 2025)
2023, Member of Organizing Committee, Sino-German Seminar on Innovation and Exchange
2019, Talent Ambassador, Hangzhou Youth Talents Workstation
2019, Director, Jiande Talent Recruitment Station (Germany)
2018, Executive Chairman, Sinodeutsche Union für Innovation e.V.
2018-2019, Chairman, 1st and 2nd China-Germany Talent Entrepreneurship and Innovation Competition of Hangzhou.Jiande
Projects
Microgel-based robots for real-time imaging-guided precise vascular selection and combined embolization-immunotherapy of hepatocellular carcinoma, RGC Junior Research Fellow Scheme, Xin Li (Principal Investigator), 2025-Now;
Design of copper sulfide nanoparticle-loaded functional nanogels for photoacoustic imaging-guided tumor photothermal therapy, Sino-German Center for Research Promotion, Xin Li (Co-Principal Investigator), 2019-2022.
Smart cationic nanogels for biomedical applications, RWTH-CSC Joint Program, Xin Li (Principal Investigator), 2018-2021.
Preparation of gold nanostar loaded hollow mesoporous silica for integration theranostics of tumor, Fundamental Rsearch Funds of the Central Universities, Xin Li (Principal Investigator), 2015-2016.
Prizes/Honours
Selected Awards
1. RGC Junior Research Fellow Award
2. PULSUS Young Scientist Award
3. JPA Best Paper Award
4. IJMS Best Promotion Ambassador
5. Winner of Poster Competition at International Conference on Next-Gen Chemistry, Chemical Engineering & Materials Technology
6. Nomination Award for 12th Chinese College Students of the Year
7. Bronze Award at 3rd China College Students’ “Internet+” Innovation and Entrepreneurship Competition
8. Nomination Award for 2015 Chinese College Students Self-improvement Star
9. Third Prize at 3rd Chinese Mathematics Competitions for College Students (CMC)
10. National Scholarship (3 times)
Patents
Selected Patents
1. Preparation and Application of An Ultrafast Charge-Reversible Chitosan-Based Nanogel, China Patent, CN 112190549B.
2. Preparation and Application of An Electrically Active and Degradable Supramolecular Microgel/Drug-loaded Supramolecular Microgel, China Patent, CN 110538139B.
3. Preparation and Application of α-Tocopherol Succinate-Conjugated Molybdenum Disulfide Nanosheets, China Patent, CN 112957468B.
4. Preparation and Application of A Polydopamine-Coated Gold Core/Hollow Silica Shell Nanomaterial, China Patent, CN 108837161B.
5. Preparation Method of FA-Targeted Low-Generation Dendrimer-Based Dual-Modal SPECT/CT Imaging Agent, China Patent, CN 105251028B.
6. Preparation and Application of An Anticancer Drug-Loaded Injectable Nanofibrous Short Fiber, China Patent, CN 106924171B.
7. Preparation Method of A Dendrimer-Stabilized Ultrasmall Iron Oxide-Gold Nanoflowers, China Patent, CN 108514642B.
8. Preparation and Application of Photo-Responsive Polymerizable Ultrasmall Iron Oxide Nanoprobe, China Patent, CN 108635595B.
9. Preparation Method of A Gold Nanostar-Loaded Hollow Mesoporous Silica, China Patent, CN 105561345B.
10. Preparation Method of A Poly(Lactic-co-Glycolic Acid)-Based Composite Nanofiber Membrane with High-Efficiency Mercury Ion Adsorption, China Patent, CN 106607014B.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 2 Zero Hunger
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SDG 3 Good Health and Well-being
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SDG 6 Clean Water and Sanitation
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SDG 7 Affordable and Clean Energy
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SDG 9 Industry, Innovation, and Infrastructure
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SDG 17 Partnerships for the Goals
Fingerprint
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Collaborations from the last five years
Research output
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Functional Dendrimer Nanogels for DNA Delivery and Gene Therapy of Tumors
Li, X. (Co-first Author), Ouyang, Z. (Co-first Author), Hetjens, L., Ni, M., Lin, K., Hu, Y., Shi, X. & Pich, A., 21 Jul 2025, In: Angewandte Chemie - International Edition. 64, 30, 11 p., e202505669.Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
Open AccessFile33 Link opens in a new tab Citations (Scopus) -
Sprayed Aqueous Microdroplets for Spontaneous Synthesis of Functional Microgels
Li, X., Zhang, W., Li, H., Shuai, Q., Zhang, X. & Pich, A., 17 Feb 2025, In: Angewandte Chemie International Edition. 64, 8, e202420926.Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
Open AccessFile16 Link opens in a new tab Citations (Scopus)3 Downloads (CityUHK Scholars) -
Transvascular transport of nanocarriers for tumor delivery
Li, X., Hu, Y., Zhang, X., Shi, X., Parak, W. J. & Pich, A., 17 Sept 2024, In: Nature Communications. 15, 8172.Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
Open AccessFile68 Link opens in a new tab Citations (Scopus) -
Leukocyte-nanomedicine system for targeted delivery and precise theragnostics
Li, X. (Co-first Author), Lu, Y. (Co-first Author), Kong, L., Shi, X. & Pich, A., Oct 2022, In: Chem. 8, 10, p. 2591-2593 3 p.Research output: Journal Publications and Reviews › Comment/debate › peer-review
5 Link opens in a new tab Citations (Scopus) -
Multi-Responsive Biodegradable Cationic Nanogels for Highly Efficient Treatment of Tumors
Li, X., Sun, H., Li, H., Hu, C., Luo, Y., Shi, X. & Pich, A., Jun 2021, In: Advanced Functional Materials. 31, 26, 2100227.Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
Open AccessFile86 Link opens in a new tab Citations (Scopus)1 Downloads (CityUHK Scholars)
Projects
- 1 Active
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JRFS: Microgel-Based Robots for Real-Time Imaging-Guided Precise Vascular Selection and Combined Embolization-Immunotherapy of Hepatocellular Carcinoma
LI, X. (Principal Investigator / Project Coordinator)
1/08/25 → …
Project: Research
Prizes
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2025-2026 RGC Junior Research Fellow Award
LI, X. (Recipient), 2025
Prize: RGC 64B - Prizes and awards
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Winner of Poster Competition at International Conference on Next-Gen Chemistry, Chemical Engineering & Materials Technology
LI, X. (Recipient), 2025
Prize: RGC 64B - Prizes and awards
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Young Scientist Award at 3rd Global Experts Meeting on Chemistry and Medicinal Chemistry
LI, X. (Recipient), 2021
Prize: RGC 64B - Prizes and awards
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Bronze Award at 3rd China College Students’ “Internet+” Innovation and Entrepreneurship Competition
LI, X. (Recipient), 2017
Prize: RGC 64B - Prizes and awards