ZnL2-BPs Integrated Bone Scallold under Sequential Photothermal Mediation : A Win-Win Strategy Delivering Antibacterial Therapy and Fostering Osteogenesis Thereafter

Research output: Conference Papers (RGC: 31A, 31B, 32, 33)32_Refereed conference paper (without host publication)peer-review

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Detail(s)

Original languageEnglish
Publication statusPublished - 13 Apr 2023

Conference

Title2023 Materials Research Society Spring Meeting and Exhibit (2023 MRS)
LocationMoscone West Convention Center & San Francisco Marriott (April 10–14, 2023) ; Virtual (April 25–27, 2023)
PlaceUnited States
CitySan Francisco
Period10 - 27 April 2023

Abstract

Implant-related infections are serious complications after bone surgery and can compromise the intended functions of artificial implants, leading to surgical failure and even amputation in severe cases. Various strategies have been proposed to endow bone implants with desirable antibacterial properties, but unfortunately, most of them inevitably suffer from some side effects detrimental to normal tissues. In this study, a multifunctional bone implant is designed to work in conjunction with sequential photothermal mediation, which can deliver antibacterial therapy (<50 °C) in the early stage and foster bone regeneration (40–42 °C) subsequently. Black phosphorus nanosheets (BPs) are coordinated with zinc sulfonate ligand (ZnL2), and the ZnL2-BPs are integrated into the surface of hydroxylapatite (HA) scaffold to produce ZnL2-BPs@HAP. In this design, BPs produce the photothermal effects and ZnL2 increases the thermal sensitivity of peri-implant bacteria by inducing envelope stress. The biosafety of the antibacterial photothermal treatment is improved due to the mild temperature, and furthermore, the gradual release of Zn2+ and PO43– from the scaffold facilitates osteogenesis in the subsequent stage of bone healing. This strategy not only broadens the biomedical applications of photothermal treatment but also provides insights into the design of multifunctional biomaterials in other fields.

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Citation Format(s)

ZnL2-BPs Integrated Bone Scallold under Sequential Photothermal Mediation: A Win-Win Strategy Delivering Antibacterial Therapy and Fostering Osteogenesis Thereafter. / Wu, Yuzheng; Chu, Paul.
2023. Paper presented at 2023 Materials Research Society Spring Meeting and Exhibit (2023 MRS), San Francisco, California, United States.

Research output: Conference Papers (RGC: 31A, 31B, 32, 33)32_Refereed conference paper (without host publication)peer-review