Zn/Ag micro-galvanic couples formed on titanium and osseointegration effects in the presence of S.aureus

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

55 Scopus Citations
View graph of relations

Author(s)

  • Guodong Jin
  • Hui Qin
  • Huiliang Cao
  • Yuqin Qiao
  • Yaochao Zhao
  • Xiaochun Peng
  • Xianlong Zhang
  • Xuanyong Liu

Detail(s)

Original languageEnglish
Pages (from-to)22-31
Journal / PublicationBiomaterials
Volume65
Online published23 Jun 2015
Publication statusPublished - Oct 2015

Abstract

Titanium implants possessing simultaneous osseointegration and antibacterial ability are desirable. In this work, three types of Zn/Ag micro-galvanic couples are fabricated on titanium by plasma immersion ion implantation to investigate the osseointegration and antibacterial effects as well as the involved mechanisms. The invitro findings disclose enhanced proliferation, osteogenic differentiation, and gene expressions of the rat bone mesenchymal stem cells (rBMSCs), as well as good antibacterial ability on all three micro-galvanic couples. Excellent antimicrobial ability is also observed invivo and the micro-CT and histological results reveal notable osseointegration invivo despite the presence of bacteria. The Zn/Ag micro-galvanic couple formed on Zn/Ag dual-ion co-implanted titanium shows the best osseointegration as well as good antibacterial properties invivo obtained from a rabbit tibia model. The difference among the three Zn/Ag micro-galvanic couples can be ascribed to the contact between the Ag NPs and Zn film, which affects the corrosion process. Our results indicate that the biological behavior can be controlled by the corrosion process of the Zn/Ag micro-galvanic couples.

Research Area(s)

  • Antibacterial ability, Micro-galvanic couple, Osseointegration, Silver, Titanium, Zinc

Citation Format(s)

Zn/Ag micro-galvanic couples formed on titanium and osseointegration effects in the presence of S.aureus. / Jin, Guodong; Qin, Hui; Cao, Huiliang; Qiao, Yuqin; Zhao, Yaochao; Peng, Xiaochun; Zhang, Xianlong; Liu, Xuanyong; Chu, Paul K.

In: Biomaterials, Vol. 65, 10.2015, p. 22-31.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal