Zinc oxide nanoparticles induce cell filamentation in escherichia coli

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Detail(s)

Original languageEnglish
Pages (from-to)375-380
Journal / PublicationParticle and Particle Systems Characterization
Volume30
Issue number4
Publication statusPublished - Apr 2013

Abstract

Zinc oxide nanoparticles (ZnO NPs) induce morphological transformation of Escherichia coli from its native rod-shape of ≈2-4 μm to filamentous cells of 20-40 μm in length. The transient response can only be observed at up to 3.5 h proliferation, beyond which the cytotoxic effect is neutralized and the rod-shape is restored. The filamentation is part of the bacterium SOS response to the Trojan horse-type internalization of undissolved ZnO solids. In the absence of ZnO solids, no cell filamentation can be observed from the leached soluble zinc fraction or dissolved zinc salt. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Research Area(s)

  • cell filamentation, cytotoxicity, leaching, undissolved solids, zinc oxide nanoparticles

Citation Format(s)

Zinc oxide nanoparticles induce cell filamentation in escherichia coli. / Gunawan, Cindy; Teoh, Wey Yang; Ricardo; Marquis, Christopher P.; Amal, Rose.

In: Particle and Particle Systems Characterization, Vol. 30, No. 4, 04.2013, p. 375-380.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review