Zebra Alphaherpesviruses (EHV-1 and EHV-9) : Genetic Diversity, Latency and Co-Infections

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

9 Scopus Citations
View graph of relations

Author(s)

  • Azza Abdelgawad
  • Armando Damiani
  • Simon Y. W. Ho
  • Günter Strauss
  • Claudia A. Szentiks
  • Marion L. East
  • Alex D. Greenwood

Detail(s)

Original languageEnglish
Article number262
Journal / PublicationViruses
Volume8
Issue number9
Online published20 Sep 2016
Publication statusPublished - Sep 2020
Externally publishedYes

Abstract

Alphaherpesviruses are highly prevalent in equine populations and co-infections with more than one of these viruses’ strains frequently diagnosed. Lytic replication and latency with subsequent reactivation, along with new episodes of disease, can be influenced by genetic diversity generated by spontaneous mutation and recombination. Latency enhances virus survival by providing an epidemiological strategy for long-term maintenance of divergent strains in animal populations. The alphaherpesviruses equine herpesvirus 1 (EHV-1) and 9 (EHV-9) have recently been shown to cross species barriers, including a recombinant EHV-1 observed in fatal infections of a polar bear and Asian rhinoceros. Little is known about the latency and genetic diversity of EHV-1 and EHV-9, especially among zoo and wild equids. Here, we report evidence of limited genetic diversity in EHV-9 in zebras, whereas there is substantial genetic variability in EHV-1. We demonstrate that zebras can be lytically and latently infected with both viruses concurrently. Such a co-occurrence of infection in zebras suggests that even relatively slow-evolving viruses such as equine herpesviruses have the potential to diversify rapidly by recombination. This has potential consequences for the diagnosis of these viruses and their management in wild and captive equid populations.

Research Area(s)

  • Co-occurrence, Diversity, EHV-1, EHV-9, Latency, Zebra

Citation Format(s)

Zebra Alphaherpesviruses (EHV-1 and EHV-9) : Genetic Diversity, Latency and Co-Infections. / Abdelgawad, Azza; Damiani, Armando; Ho, Simon Y. W.; Strauss, Günter; Szentiks, Claudia A.; East, Marion L.; Osterrieder, Nikolaus; Greenwood, Alex D.

In: Viruses, Vol. 8, No. 9, 262, 09.2020.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review