Yolk shell nanocomposite particles as bioactive bone fillers and growth factor carriers

Pujiang Shi; Sunny A. Abbah; Yon Jin Chuah; Jun Li; Yong Zhang; Pengfei He; Hee Kit Wong; James C. H. Goh

doi:10.1039/c7nr03093b

Yolk shell nanocomposite particles as bioactive bone fillers and growth factor carriers

Pujiang Shi
, Sunny A. Abbah
, Yon Jin Chuah
, Jun Li
, Yong Zhang
, Pengfei He
, Hee Kit Wong
, James C. H. Goh^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

8 Citations (Scopus)

Abstract

The efficient delivery of bioactive molecules via rationally designed nanoparticles is an important focus in regenerative medicine. The yolk shell nanocomposite particles described herein are composed of silk fibroin movable cores formed within voided calcium carbonate shells to load and control the release of labile cytokines. These particles are excellent carrier vehicles of potent molecules as they sustained the release of bioactive Bone Morphogenetic Protein 2 (BMP-2) for more than 28 days in vitro. Implantation into bone defects in rabbits corroborates the in vitro results and also reveals that upon contact with phosphate containing body fluids, implanted yolk shell particles agglomerate and transform into a filler that adapts to defect contour to further act as an absorbable hemostatic agent. Taken together, the fabrication of these yolk shell particle-based "bone fillers" could expand the horizon for the development of newer generations of advanced bioactive materials in tissue regeneration applications. © 2017 The Royal Society of Chemistry.

Original language	English
Pages (from-to)	14520-14532
Journal	Nanoscale
Volume	9
Issue number	38
DOIs	https://doi.org/10.1039/c7nr03093b
Publication status	Published - 14 Oct 2017
Externally published	Yes

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Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

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title = "Yolk shell nanocomposite particles as bioactive bone fillers and growth factor carriers",

abstract = "The efficient delivery of bioactive molecules via rationally designed nanoparticles is an important focus in regenerative medicine. The yolk shell nanocomposite particles described herein are composed of silk fibroin movable cores formed within voided calcium carbonate shells to load and control the release of labile cytokines. These particles are excellent carrier vehicles of potent molecules as they sustained the release of bioactive Bone Morphogenetic Protein 2 (BMP-2) for more than 28 days in vitro. Implantation into bone defects in rabbits corroborates the in vitro results and also reveals that upon contact with phosphate containing body fluids, implanted yolk shell particles agglomerate and transform into a filler that adapts to defect contour to further act as an absorbable hemostatic agent. Taken together, the fabrication of these yolk shell particle-based {"}bone fillers{"} could expand the horizon for the development of newer generations of advanced bioactive materials in tissue regeneration applications. {\textcopyright} 2017 The Royal Society of Chemistry.",

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T1 - Yolk shell nanocomposite particles as bioactive bone fillers and growth factor carriers

AU - Shi, Pujiang

AU - Abbah, Sunny A.

AU - Chuah, Yon Jin

AU - Li, Jun

AU - Zhang, Yong

AU - He, Pengfei

AU - Wong, Hee Kit

AU - Goh, James C. H.

N1 - Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

PY - 2017/10/14

Y1 - 2017/10/14

N2 - The efficient delivery of bioactive molecules via rationally designed nanoparticles is an important focus in regenerative medicine. The yolk shell nanocomposite particles described herein are composed of silk fibroin movable cores formed within voided calcium carbonate shells to load and control the release of labile cytokines. These particles are excellent carrier vehicles of potent molecules as they sustained the release of bioactive Bone Morphogenetic Protein 2 (BMP-2) for more than 28 days in vitro. Implantation into bone defects in rabbits corroborates the in vitro results and also reveals that upon contact with phosphate containing body fluids, implanted yolk shell particles agglomerate and transform into a filler that adapts to defect contour to further act as an absorbable hemostatic agent. Taken together, the fabrication of these yolk shell particle-based "bone fillers" could expand the horizon for the development of newer generations of advanced bioactive materials in tissue regeneration applications. © 2017 The Royal Society of Chemistry.

AB - The efficient delivery of bioactive molecules via rationally designed nanoparticles is an important focus in regenerative medicine. The yolk shell nanocomposite particles described herein are composed of silk fibroin movable cores formed within voided calcium carbonate shells to load and control the release of labile cytokines. These particles are excellent carrier vehicles of potent molecules as they sustained the release of bioactive Bone Morphogenetic Protein 2 (BMP-2) for more than 28 days in vitro. Implantation into bone defects in rabbits corroborates the in vitro results and also reveals that upon contact with phosphate containing body fluids, implanted yolk shell particles agglomerate and transform into a filler that adapts to defect contour to further act as an absorbable hemostatic agent. Taken together, the fabrication of these yolk shell particle-based "bone fillers" could expand the horizon for the development of newer generations of advanced bioactive materials in tissue regeneration applications. © 2017 The Royal Society of Chemistry.

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U2 - 10.1039/c7nr03093b

DO - 10.1039/c7nr03093b

M3 - RGC 21 - Publication in refereed journal

C2 - 28930342

SN - 2040-3364

VL - 9

SP - 14520

EP - 14532

JO - Nanoscale

JF - Nanoscale

IS - 38

ER -

Yolk shell nanocomposite particles as bioactive bone fillers and growth factor carriers

Abstract

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