A wideband highly isolated multiple-input-multiple-output patch antenna with an artificial magnetic conductor (AMC) ground plane is proposed in this letter. The antenna, which is rotationally symmetrical, is constructed by V-shaped patches coupled by a bowtie dipole. The bowtie dipole and the V-shaped parasitic patches produce two resonant modes that are coupled together. Therefore, a wide impedance bandwidth is obtained. Thanks to the orthogonal feeding and the rotationally symmetrical geometry, the antenna exhibits high port isolation as well as symmetrical radiation patterns with a compact size of 40 × 40 × 1.524 mm3. By placing an AMC ground plane with a distance of 10.5 mm below the radiating element, the antenna can achieve a unidirectional high gain with a lower height of the profile compared to that with perfect electrical conductor ground. Measured results show the antenna has an impedance bandwidth of 31.0% (3.0-4.1 GHz) with port isolation better than 25 dB. The peak gain can reach 7.1 dBi with stable and symmetrical radiation patterns.