@inproceedings{9d64a7605bef4326ba758d57d2d465d3,
title = "Wide-field photoacoustic microscopy of oxygen saturation at 1-MHz A-line rate",
abstract = "We report wide-field polygon-scanning optical-resolution photoacoustic microscopy (OR-PAM) that achieves 1-MHz A-line rate of oxygen saturation in vivo. We develop a polygon-scanning imaging probe. Using stimulated Raman scattering and optical delay in fiber, we develop a dual-wavelength pulsed laser that has proper wavelengths, sufficient pulse energy, high pulse repetition rate, and sub-microseconds wavelength switching time for fast imaging of oxygen saturation. The OR-PAM system offers a 478-Hz B-scan rate and a 1-Hz volumetric imaging rate over a 12×5 mm2 scanning area. We demonstrate dynamic imaging of oxygen saturation of fast response to epinephrine injection in the mouse ear. Results show fast hemodynamic and functional changes in centimeter-sized areas.",
keywords = "fast imaging, functional imaging, oxygen saturation, Photoacoustic microscopy, wide-field",
author = "Jiangbo Chen and Yachao Zhang and Linyun He and Yizhi Liang and Lidai Wang",
year = "2021",
doi = "10.1117/12.2577486",
language = "English",
isbn = "9781510641198",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
editor = "Oraevsky, {Alexander A.} and Wang, {Lihong V.}",
booktitle = "Photons Plus Ultrasound",
address = "United States",
note = "SPIE BiOS 2021 Digital Forum ; Conference date: 06-03-2021 Through 11-03-2021",
}