White Matter Vulnerability to Ischemic Injury Increases with Age Because of Enhanced Excitotoxicity

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Selva Baltan
  • Elaine F. Besancon
  • Brianna Mbow
  • ZuCheng Ye
  • Margaret A. Hamner

Detail(s)

Original languageEnglish
Pages (from-to)1479-1489
Journal / PublicationJournal of Neuroscience
Volume28
Issue number6
Publication statusPublished - 6 Feb 2008
Externally publishedYes

Abstract

Stroke incidence increases with age and this has been attributed to vascular factors. We show here that CNS white matter (WM) is intrinsically more vulnerable to ischemic injury in older animals and that the mechanisms of WM injury change as a function of age. The mouse optic nerve was used to study WM function. WM function in older animals (12 months) was not protected from ischemic injury by removal of extracellular Ca2+ or by blockade of reverse Na+/Ca2+ exchange, as is the case with young adults. Ischemic WM injury in older mice is predominately mediated by glutamate release and activation of AMPA/kainate-type glutamate receptors. Glutamate release, attributable to reverse glutamate transport, occurs earlier and is more robust in older mice that show greater expression of the glutamate transporter. The observation that WM vulnerability to ischemic injury is age dependent has possible implications for the pathogenesis of other age-related CNS conditions. Copyright © 2008 Society for Neuroscience.

Research Area(s)

  • AMPA/kainate receptors, Axon, Glutamate, Glutamate transporter, NMDA receptors, Stroke

Citation Format(s)

White Matter Vulnerability to Ischemic Injury Increases with Age Because of Enhanced Excitotoxicity. / Baltan, Selva; Besancon, Elaine F.; Mbow, Brianna; Ye, ZuCheng; Hamner, Margaret A.; Ransom, Bruce R.

In: Journal of Neuroscience, Vol. 28, No. 6, 06.02.2008, p. 1479-1489.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review