When MT1-MMP meets ADAMs

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)62_Review of books or of software (or similar publications/items)

10 Scopus Citations
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Author(s)

  • Hoi Leong Xavier Wong
  • Renhai Cao
  • Guoxiang Jin
  • Yihai Cao
  • Zhongjun Zhou

Detail(s)

Original languageEnglish
Pages (from-to)2793-2798
Journal / PublicationCell Cycle
Volume11
Issue number15
Publication statusPublished - 1 Aug 2012
Externally publishedYes

Abstract

MT1-MMP is a membrane-tethered enzyme capable of remodeling extracellular matrix. MT1-MMP-deficient mice exhibit systematic defects during development, especially in craniofacial development characterized by retarded calvarial bone formation. Recently, we identified MT1-MMP as a critical positive modulator of FGF signaling during intramembranous ossification. MT1-MMP cleaves ADAM9 to protect FGFR2 from ectodomain shedding. Depletion of ADAM9 in MT1-MMP-deficient mice significantly rescued the calvarial defects via restoring FGF signaling. Interestingly, this regulatory mechanism seems to be highly tissue-specific, as defective FGF2-induced corneal angiogenesis in Mmp14-/- mice could not be rescued by removal of ADAM9. In addition, MT1-MMP also cleaves another ADAM family member, ADAM15. Our current findings not only present a novel regulatory mechanism for FGF signaling but also reveal a functional crosstalk between MMP and ADAM families. Better understanding of the interplay between ADAMs and MT1-MMP and its consequences for signaling pathways will provide new insights into therapeutic approaches for the management of developmental disorders and various diseases, such as cancer. © 2012 Landes Bioscience.

Research Area(s)

  • ADAM15, ADAM9, Angiogenesis, FGF signaling, MT1-MMP, Osteogenesis

Citation Format(s)

When MT1-MMP meets ADAMs. / Wong, Hoi Leong Xavier; Cao, Renhai; Jin, Guoxiang; Chan, Kui Ming; Cao, Yihai; Zhou, Zhongjun.

In: Cell Cycle, Vol. 11, No. 15, 01.08.2012, p. 2793-2798.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)62_Review of books or of software (or similar publications/items)