Wearable patches for transdermal drug delivery

Jiahui He; Yuyue Zhang; Xinge Yu; Chenjie Xu

doi:10.1016/j.apsb.2023.05.009

Wearable patches for transdermal drug delivery

Jiahui He
, Yuyue Zhang
, Xinge Yu
, Chenjie Xu^*

^*Corresponding author for this work

Department of Biomedical Engineering

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

79 Citations (Scopus)

142 Downloads (CityUHK Scholars)

Abstract

Transdermal drug delivery systems (TDDs) avoid gastrointestinal degradation and hepatic first-pass metabolism, providing good drug bioavailability and patient compliance. One emerging type of TDDs is the wearable patch worn on the skin surface to deliver medication through the skin. They can generally be grouped into passive and active types, depending on the properties of materials, design principles and integrated devices. This review describes the latest advancement in the development of wearable patches, focusing on the integration of stimulus-responsive materials and electronics. This development is deemed to provide a dosage, temporal, and spatial control of therapeutics delivery. © 2023 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences

Original language	English
Pages (from-to)	2298-2309
Journal	Acta Pharmaceutica Sinica B
Volume	13
Issue number	6
Online published	15 May 2023
DOIs	https://doi.org/10.1016/j.apsb.2023.05.009
Publication status	Published - Jun 2023

Funding

Chenjie Xu appreciates the support by Strategic Interdisciplinary Research Grant (7020029) from City University of Hong Kong, General Research Fund (GRF) grant from the Research Grants Council (RGC) of the Hong Kong Special Administrative Region, China (CityU 11200820, 11202222), and the Mainland/Hong Kong Joint Research Scheme sponsored by the RGC Hong Kong and the National Natural Science Foundation of China (N_CityU118/20). Xinge Yu acknowledges the Inno HK funding support from the Hong Kong Centre for Cerebro-cardiovascular Health Engineering (COCHE)

Research Keywords

Biomaterials
Drug delivery
Microneedles
Transdermal delivery
Wearable patch

Publisher's Copyright Statement

This full text is made available under CC-BY-NC-ND 4.0. https://creativecommons.org/licenses/by-nc-nd/4.0/

RGC Funding Information

RGC-funded

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10.1016/j.apsb.2023.05.009

155088878.pdfFinal Published version, 2.75 MBLicence: CC BY-NC-ND

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title = "Wearable patches for transdermal drug delivery",

abstract = "Transdermal drug delivery systems (TDDs) avoid gastrointestinal degradation and hepatic first-pass metabolism, providing good drug bioavailability and patient compliance. One emerging type of TDDs is the wearable patch worn on the skin surface to deliver medication through the skin. They can generally be grouped into passive and active types, depending on the properties of materials, design principles and integrated devices. This review describes the latest advancement in the development of wearable patches, focusing on the integration of stimulus-responsive materials and electronics. This development is deemed to provide a dosage, temporal, and spatial control of therapeutics delivery. {\textcopyright} 2023 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences",

keywords = "Biomaterials, Drug delivery, Microneedles, Transdermal delivery, Wearable patch",

author = "Jiahui He and Yuyue Zhang and Xinge Yu and Chenjie Xu",

year = "2023",

month = jun,

doi = "10.1016/j.apsb.2023.05.009",

language = "English",

volume = "13",

pages = "2298--2309",

journal = "Acta Pharmaceutica Sinica B",

issn = "2211-3835",

publisher = "Elsevier B.V.",

number = "6",

}

TY - JOUR

T1 - Wearable patches for transdermal drug delivery

AU - He, Jiahui

AU - Zhang, Yuyue

AU - Yu, Xinge

AU - Xu, Chenjie

PY - 2023/6

Y1 - 2023/6

N2 - Transdermal drug delivery systems (TDDs) avoid gastrointestinal degradation and hepatic first-pass metabolism, providing good drug bioavailability and patient compliance. One emerging type of TDDs is the wearable patch worn on the skin surface to deliver medication through the skin. They can generally be grouped into passive and active types, depending on the properties of materials, design principles and integrated devices. This review describes the latest advancement in the development of wearable patches, focusing on the integration of stimulus-responsive materials and electronics. This development is deemed to provide a dosage, temporal, and spatial control of therapeutics delivery. © 2023 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences

AB - Transdermal drug delivery systems (TDDs) avoid gastrointestinal degradation and hepatic first-pass metabolism, providing good drug bioavailability and patient compliance. One emerging type of TDDs is the wearable patch worn on the skin surface to deliver medication through the skin. They can generally be grouped into passive and active types, depending on the properties of materials, design principles and integrated devices. This review describes the latest advancement in the development of wearable patches, focusing on the integration of stimulus-responsive materials and electronics. This development is deemed to provide a dosage, temporal, and spatial control of therapeutics delivery. © 2023 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences

KW - Biomaterials

KW - Drug delivery

KW - Microneedles

KW - Transdermal delivery

KW - Wearable patch

UR - https://www.scopus.com/pages/publications/85160688503

UR - https://www.scopus.com/pages/publications/85160688503#tab=impact

U2 - 10.1016/j.apsb.2023.05.009

DO - 10.1016/j.apsb.2023.05.009

M3 - RGC 21 - Publication in refereed journal

C2 - 37425057

SN - 2211-3835

VL - 13

SP - 2298

EP - 2309

JO - Acta Pharmaceutica Sinica B

JF - Acta Pharmaceutica Sinica B

IS - 6

ER -

Wearable patches for transdermal drug delivery

Abstract

Funding

Research Keywords

Publisher's Copyright Statement

RGC Funding Information

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GRF: The Second Generation of Cryomicroneedles for Transdermal Cell Delivery in Cancer Immunotherapy

GRF: Development of Highly Swellable Microneedle Skin Patches for Skin Interstitial Fluid Sampling and In Situ Transdermal Biosensing

NSFC: Nanometallic Conductive Composite-hydrogel Core-shell Microneedle Skin Patch for Real-time Monitoring Physiological Signals

Cite this

Wearable patches for transdermal drug delivery

Abstract

Funding

Research Keywords

Publisher's Copyright Statement

RGC Funding Information

Access Output

Other Access Options

Permanent Link

Other Files and Links

Fingerprint

Projects

GRF: The Second Generation of Cryomicroneedles for Transdermal Cell Delivery in Cancer Immunotherapy

GRF: Development of Highly Swellable Microneedle Skin Patches for Skin Interstitial Fluid Sampling and In Situ Transdermal Biosensing

NSFC: Nanometallic Conductive Composite-hydrogel Core-shell Microneedle Skin Patch for Real-time Monitoring Physiological Signals

Cite this