Water-soluble fluorescent probes for differentiating cancer cells and normal cells by tracking lysosomal viscosity

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

6 Scopus Citations
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Author(s)

  • Minghui Liu
  • Jintao Weng
  • Shumei Huang
  • Wenjin Yin
  • Huatang Zhang
  • Yin Jiang
  • Liu Yang

Detail(s)

Original languageEnglish
Pages (from-to)3570-3573
Journal / PublicationChemical Communications
Volume59
Issue number24
Online published27 Feb 2023
Publication statusPublished - 25 Mar 2023

Abstract

Lysosomal viscosity is a significant parameter of lysosomes and closely related to various diseases. Herein, two fluorescent probes, Lyso-vis-A and Lyso-vis-B, were developed, which demonstrate diverse advantages, including great water solubility, lysosome targeting ability and viscosity sensitivity. In particular, Lyso-vis-A exclusively showed fluorescence response toward viscosity but was not influenced by pH changes, rendering it a selective lysosomal viscosity probe. Furthermore, Lyso-vis-A was successfully applied to monitor lysosomal viscosity variations in living cells and differentiate cancer cells and normal cells. © The Royal Society of Chemistry 2023.

Citation Format(s)

Water-soluble fluorescent probes for differentiating cancer cells and normal cells by tracking lysosomal viscosity. / Liu, Minghui; Weng, Jintao; Huang, Shumei et al.
In: Chemical Communications, Vol. 59, No. 24, 25.03.2023, p. 3570-3573.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review