Water-Soluble Polythiophene for Two-Photon Excitation Fluorescence Imaging and Photodynamic Therapy of Cancer

Minhuan Lan; Shaojing Zhao; Yusheng Xie; Junfang Zhao; Liang Guo; Guangle Niu; Ying Li; Hongyan Sun; Hongyan Zhang; Weimin Liu; Jinyuan Zhang; Pengfei Wang; Wenjun Zhang

doi:10.1021/acsami.6b15537

Water-Soluble Polythiophene for Two-Photon Excitation Fluorescence Imaging and Photodynamic Therapy of Cancer

Minhuan Lan, Shaojing Zhao, Yusheng Xie, Junfang Zhao, Liang Guo, Guangle Niu, Ying Li, Hongyan Sun, Hongyan Zhang, Weimin Liu, Jinyuan Zhang, Pengfei Wang^*, Wenjun Zhang^*

^*Corresponding author for this work

Centre of Super-Diamond and Advanced Films

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

52 Citations (Scopus)

Abstract

Positively charged water-soluble polythiophene (PT0) that could self-assemble into nanoparticles in pure water solution was designed and synthesized. PT0 exhibited high photostabilities and pH stabilities, excellent biocompatibility, strong ¹O₂ generation capability, and large two-photon absorption cross sections. Moreover, we showed that the fluorescence of PT0 was unaffected by the interference of biomolecules and metal ions. As an example application, PT0 was demonstrated to be capable of simultaneous cell imaging and photodynamic therapy under either one-photon or two-photon excitation modes.

Original language	English
Pages (from-to)	14590-14595
Journal	ACS Applied Materials and Interfaces
Volume	9
Issue number	17
Online published	12 Apr 2017
DOIs	https://doi.org/10.1021/acsami.6b15537
Publication status	Published - 3 May 2017

Research Keywords

conjugated polymer
fluorescence imaging
PDT
two photon

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Water-Soluble Polythiophene for Two-Photon Excitation Fluorescence Imaging and Photodynamic Therapy of Cancer",

abstract = "Positively charged water-soluble polythiophene (PT0) that could self-assemble into nanoparticles in pure water solution was designed and synthesized. PT0 exhibited high photostabilities and pH stabilities, excellent biocompatibility, strong 1O2 generation capability, and large two-photon absorption cross sections. Moreover, we showed that the fluorescence of PT0 was unaffected by the interference of biomolecules and metal ions. As an example application, PT0 was demonstrated to be capable of simultaneous cell imaging and photodynamic therapy under either one-photon or two-photon excitation modes.",

keywords = "conjugated polymer, fluorescence imaging, PDT, two photon",

author = "Minhuan Lan and Shaojing Zhao and Yusheng Xie and Junfang Zhao and Liang Guo and Guangle Niu and Ying Li and Hongyan Sun and Hongyan Zhang and Weimin Liu and Jinyuan Zhang and Pengfei Wang and Wenjun Zhang",

year = "2017",

month = may,

day = "3",

doi = "10.1021/acsami.6b15537",

language = "English",

volume = "9",

pages = "14590--14595",

journal = "ACS Applied Materials and Interfaces",

issn = "1944-8244",

publisher = "American Chemical Society",

number = "17",

}

TY - JOUR

T1 - Water-Soluble Polythiophene for Two-Photon Excitation Fluorescence Imaging and Photodynamic Therapy of Cancer

AU - Lan, Minhuan

AU - Zhao, Shaojing

AU - Xie, Yusheng

AU - Zhao, Junfang

AU - Guo, Liang

AU - Niu, Guangle

AU - Li, Ying

AU - Sun, Hongyan

AU - Zhang, Hongyan

AU - Liu, Weimin

AU - Zhang, Jinyuan

AU - Wang, Pengfei

AU - Zhang, Wenjun

PY - 2017/5/3

Y1 - 2017/5/3

N2 - Positively charged water-soluble polythiophene (PT0) that could self-assemble into nanoparticles in pure water solution was designed and synthesized. PT0 exhibited high photostabilities and pH stabilities, excellent biocompatibility, strong 1O2 generation capability, and large two-photon absorption cross sections. Moreover, we showed that the fluorescence of PT0 was unaffected by the interference of biomolecules and metal ions. As an example application, PT0 was demonstrated to be capable of simultaneous cell imaging and photodynamic therapy under either one-photon or two-photon excitation modes.

AB - Positively charged water-soluble polythiophene (PT0) that could self-assemble into nanoparticles in pure water solution was designed and synthesized. PT0 exhibited high photostabilities and pH stabilities, excellent biocompatibility, strong 1O2 generation capability, and large two-photon absorption cross sections. Moreover, we showed that the fluorescence of PT0 was unaffected by the interference of biomolecules and metal ions. As an example application, PT0 was demonstrated to be capable of simultaneous cell imaging and photodynamic therapy under either one-photon or two-photon excitation modes.

KW - conjugated polymer

KW - fluorescence imaging

KW - PDT

KW - two photon

UR - http://www.scopus.com/inward/record.url?scp=85018986296&partnerID=8YFLogxK

UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-85018986296&origin=recordpage

U2 - 10.1021/acsami.6b15537

DO - 10.1021/acsami.6b15537

M3 - RGC 21 - Publication in refereed journal

C2 - 28401752

SN - 1944-8244

VL - 9

SP - 14590

EP - 14595

JO - ACS Applied Materials and Interfaces

JF - ACS Applied Materials and Interfaces

IS - 17

ER -

Water-Soluble Polythiophene for Two-Photon Excitation Fluorescence Imaging and Photodynamic Therapy of Cancer

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GRF: Group-VI Element-Doped Carbon Nanoparticles for Phototherapeutic Applications

Cite this

Water-Soluble Polythiophene for Two-Photon Excitation Fluorescence Imaging and Photodynamic Therapy of Cancer

Abstract

Research Keywords

UN SDGs

Access Output

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GRF: Group-VI Element-Doped Carbon Nanoparticles for Phototherapeutic Applications

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