Visuoauditory Associative Memory Established with Cholecystokinin Under Anesthesia Is Retrieved in Behavioral Contexts

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

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Author(s)

Detail(s)

Original languageEnglish
Pages (from-to)2025-2037
Journal / PublicationJournal of Neuroscience
Volume40
Issue number10
Publication statusPublished - 4 Mar 2020

Link(s)

Abstract

Plastic change in neuronal connectivity is the foundation of memory encoding. It is not clear whether the changes during anesthesia can alter subsequent behavior. Here, we demonstrated that in male rodents under anesthesia, a visual stimulus (VS) was associated with electrical stimulation of the auditory cortex or natural auditory stimulus in the presence of cholecystokinin (CCK), which guided the animals' behavior in a two-choice auditory task. Auditory neurons became responsive to the VS after the pairings. Moreover, high-frequency stimulation of axon terminals of entorhinal CCK neurons in the auditory cortex enabled LTP of the visual response in the auditory cortex. Such pairing during anesthesia also generated VS-induced freezing in an auditory fear conditioning task. Finally, we verified that direct inputs from the entorhinal CCK neurons and the visual cortex enabled the above neural plasticity in the auditory cortex. Our findings suggest that CCK-enabled visuoauditory association during anesthesia can be translated to the subsequent behavior action.

Research Area(s)

  • auditory cortex, cholecystokinin, entorhinal cortex, memory encoding, neural plasticity, operant conditioning, ACOUSTIC STARTLE RESPONSE, GENERAL-ANESTHESIA, NERVOUS-SYSTEM, PANIC-ATTACKS, ACTIVATION, FEAR, RAT, OCTAPEPTIDE, ANTAGONIST

Bibliographic Note

Full text of this publication does not contain sufficient affiliation information. With consent from the author(s) concerned, the Research Unit(s) information for this record is based on the existing academic department affiliation of the author(s).

Citation Format(s)

Visuoauditory Associative Memory Established with Cholecystokinin Under Anesthesia Is Retrieved in Behavioral Contexts. / Zhang, Zicong; Zheng, Xuejiao; Sun, Wenjian; Peng, Yujie; Guo, Yiping; Lu, Danyi; Zheng, Yilin; Li, Xiao; Jendrichovsky, Peter; Tang, Peng; He, Ling; Li, Min; Liu, Qing; Xu, Fuqiang; Ng, Gabriel; Chen, Xi; He, Jufang.

In: Journal of Neuroscience, Vol. 40, No. 10, 04.03.2020, p. 2025-2037.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

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