Virome characterization of game animals in China reveals a spectrum of emerging pathogens

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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Author(s)

  • Wan-Ting He
  • Xin Hou
  • Jin Zhao
  • Jiumeng Sun
  • Haijian He
  • Wei Si
  • Jing Wang
  • Zhiwen Jiang
  • Ziqing Yan
  • Gang Xing
  • Meng Lu
  • Marc A. Suchard
  • Xiang Ji
  • Wenjie Gong
  • Biao He
  • Philippe Lemey
  • Deyin Guo
  • Changchun Tu
  • Edward C. Holmes
  • Mang Shi
  • Shuo Su

Detail(s)

Original languageEnglish
Pages (from-to)1117-1129.e8
Journal / PublicationCell
Volume185
Issue number7
Online published16 Feb 2022
Publication statusPublished - 31 Mar 2022

Abstract

Game animals are wildlife species traded and consumed as food, and potential reservoirs for SARS-CoV and SARS-CoV-2. We performed a meta-transcriptomic analysis of 1941 game animals, representing 18 species and five mammalian orders, sampled across China. From this we identified 102 mammalian-infecting viruses, with 65 described for the first time. Twenty-one viruses were considered as potentially high risk to humans and domestic animals. Civets (Paguma larvata) carried the highest number of potentially high-risk viruses. We inferred the transmission of Bat coronavirus HKU8 from bats to civets, as well as cross-species jumps of coronaviruses from bats to hedgehogs, from birds to porcupines, and from dogs to raccoon dogs. Of note, we identified avian Influenza A virus H9N2 in civets and Asian badgers, with the latter displaying respiratory symptoms, as well as cases of likely human-to-wildlife virus transmission. These data highlight the importance of game animals as potential drivers of disease emergence.

Research Area(s)

  • Game animals, Virome, Disease emergence, Evolution, Coronavirus

Citation Format(s)

Virome characterization of game animals in China reveals a spectrum of emerging pathogens. / He, Wan-Ting; Hou, Xin; Zhao, Jin et al.
In: Cell, Vol. 185, No. 7, 31.03.2022, p. 1117-1129.e8.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review