Variation in Spontaneous Activity and Visual Evoked Response in Primary Visual Cortex of the S334ter-3 Rats

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Original languageEnglish
Article number03034
Journal / PublicationE3S Web of Conferences
Online published1 Sept 2020
Publication statusPublished - 2020


Title2020 International Conference on Energy, Environment and Bioengineering (ICEEB 2020)
Period7 - 9 August 2020



S334ter-3 retinal degeneration (RD) rats have been widely used to investigate degenerative diseases of the retina. In this model, morphological and electrophysiological changes have been observed in the retina, superior colliculus and primary visual cortex (V1). In this study, experimental rats (S334ter-3) carried one copy of the mutant transgene. We measured the extracellular responses in the primary visual cortex to three stimulus contrast levels (spontaneous activity, medium contrast, and high contrast) at the preferred parameters of each recorded cell under classical receptive field (CRF) stimulation. Then we compared the responses (spontaneous activity and the visual evoked responses) in RD rats with those in wildtype rats. Our results show that V1 cells in the RD group exhibit stronger spontaneous activity but weaker stimulus-evoked responses at medium and high contrasts. At the same time, compared with WT group, RD group also showed a narrow dynamic range. These results indicate the decrease in discriminating the stimuli contrast and loss in responses and lower signal to noise ratio after retina degeneration.

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