Variability in viral pathogenesis: modeling the dynamic of acute and persistent infections

Peter V Lidsky; Raul Andino; Igor M Rouzine

doi:10.1016/j.coviro.2017.05.001

Variability in viral pathogenesis: modeling the dynamic of acute and persistent infections

Peter V Lidsky
, Raul Andino
, Igor M Rouzine

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

6 Citations (Scopus)

Abstract

Virus infection often results in diverse outcomes. This variability of virus pathogenesis is not well understood. Here we revise theoretical arguments to further our understanding of factors controlling infection and its severity. We propose that variability in these factors results in different clinical outcomes, which ultimately ensure virus reproduction. © 2017 Elsevier B.V.

Original language	English
Pages (from-to)	120-124
Journal	Current Opinion in Virology
Volume	23
DOIs	https://doi.org/10.1016/j.coviro.2017.05.001
Publication status	Published - 1 Apr 2017
Externally published	Yes

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Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

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title = "Variability in viral pathogenesis: modeling the dynamic of acute and persistent infections",

abstract = "Virus infection often results in diverse outcomes. This variability of virus pathogenesis is not well understood. Here we revise theoretical arguments to further our understanding of factors controlling infection and its severity. We propose that variability in these factors results in different clinical outcomes, which ultimately ensure virus reproduction. {\textcopyright} 2017 Elsevier B.V.",

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T2 - modeling the dynamic of acute and persistent infections

AU - Lidsky, Peter V

AU - Andino, Raul

AU - Rouzine, Igor M

N1 - Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

PY - 2017/4/1

Y1 - 2017/4/1

N2 - Virus infection often results in diverse outcomes. This variability of virus pathogenesis is not well understood. Here we revise theoretical arguments to further our understanding of factors controlling infection and its severity. We propose that variability in these factors results in different clinical outcomes, which ultimately ensure virus reproduction. © 2017 Elsevier B.V.

AB - Virus infection often results in diverse outcomes. This variability of virus pathogenesis is not well understood. Here we revise theoretical arguments to further our understanding of factors controlling infection and its severity. We propose that variability in these factors results in different clinical outcomes, which ultimately ensure virus reproduction. © 2017 Elsevier B.V.

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U2 - 10.1016/j.coviro.2017.05.001

DO - 10.1016/j.coviro.2017.05.001

M3 - RGC 21 - Publication in refereed journal

C2 - 28551476

SN - 1879-6257

VL - 23

SP - 120

EP - 124

JO - Current Opinion in Virology

JF - Current Opinion in Virology

ER -

Variability in viral pathogenesis: modeling the dynamic of acute and persistent infections

Abstract

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