Using a Stable Radical as an “Electron Donor” to Develop a Radical Photosensitizer for Efficient Type-I Photodynamic Therapy

Xiao Cui; Fang Fang; Huan Chen; Chen Cao; Yafang Xiao; Shuang Tian; Jinfeng Zhang; Shengliang Li; Chun Sing Lee

doi:10.1039/D4MH00952E

Using a Stable Radical as an “Electron Donor” to Develop a Radical Photosensitizer for Efficient Type-I Photodynamic Therapy

Xiao Cui (Co-first Author), Fang Fang (Co-first Author), Huan Chen (Co-first Author), Chen Cao, Yafang Xiao, Shuang Tian, Jinfeng Zhang^*, Shengliang Li^*, Chun Sing Lee^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

2 Citations (Scopus)

2 Downloads (CityUHK Scholars)

Abstract

Among type I photosensitizers, stable organic radicals are superior candidate molecules for hypoxia-overcoming photodynamic therapy. While their wide applications are limited by complicated preparation processes and poor stabilities. Herein, a nitroxide radical was simply synthesized by introducing a commercially available “TEMPO” moiety. The radical exhibit efficient type-I ROS generation, appreciable photo-cytotoxicity under hypoxia, which provides a new avenue into the exploration of novel and efficient type-I photosensitizer. © The Royal Society of Chemistry 2024

Original language	English
Pages (from-to)	1002-1007
Journal	Materials Horizons
Volume	12
Issue number	3
Online published	30 Oct 2024
DOIs	https://doi.org/10.1039/D4MH00952E
Publication status	Published - 7 Feb 2025

Funding

C.-S.L. thanks the support of the Research Grants Council of Hong Kong Special Administrative Region, General Research Fund (Project No. CityU 11318322). S.L. thanks the support of the National Natural Science Foundation of China (No. 52173135), Jiangsu Specially Appointed Professorship, Leading Talents of Innovation and Entrepreneurship of Gusu (ZXL2022496), and the Suzhou Science and Technology Program (SKY2022039). J.F. would like to thank the support of the National Natural Science Foundation of China (No. 32371442).

Publisher's Copyright Statement

COPYRIGHT TERMS OF DEPOSITED POSTPRINT FILE: This journal is © Royal Society of Chemistry. This is the accepted version of a paper published in Materials Horizons. This paper has been peer-reviewed but does not include the final publisher proof-corrections or journal pagination. Cui, X., Fang, F., Chen, H., Cao, C., Xiao, Y., Tian, S., Zhang, J., Li, S., & Lee, C. S. (2024). Using a Stable Radical as an “Electron Donor” to Develop a Radical Photosensitizer for Efficient Type-I Photodynamic Therapy. Materials Horizons. Advance online publication. https://doi.org/10.1039/D4MH00952E

RGC Funding Information

RGC-funded

Access Output

10.1039/D4MH00952E

252400765.pdfPost-print, 1.89 MB

Other Access Options

Check CityUHK Library

Permanent Link

Right click to copy link

Cite this

@article{3ba51a39c25f4709a9356e4c9670bbe2,

title = "Using a Stable Radical as an “Electron Donor” to Develop a Radical Photosensitizer for Efficient Type-I Photodynamic Therapy",

abstract = "Among type I photosensitizers, stable organic radicals are superior candidate molecules for hypoxia-overcoming photodynamic therapy. While their wide applications are limited by complicated preparation processes and poor stabilities. Herein, a nitroxide radical was simply synthesized by introducing a commercially available “TEMPO” moiety. The radical exhibit efficient type-I ROS generation, appreciable photo-cytotoxicity under hypoxia, which provides a new avenue into the exploration of novel and efficient type-I photosensitizer. {\textcopyright} The Royal Society of Chemistry 2024",

author = "Xiao Cui and Fang Fang and Huan Chen and Chen Cao and Yafang Xiao and Shuang Tian and Jinfeng Zhang and Shengliang Li and Lee, {Chun Sing}",

year = "2025",

month = feb,

day = "7",

doi = "10.1039/D4MH00952E",

language = "English",

volume = "12",

pages = "1002--1007",

journal = "Materials Horizons",

issn = "2051-6347",

publisher = "Royal Society of Chemistry",

number = "3",

}

Using a Stable Radical as an “Electron Donor” to Develop a Radical Photosensitizer for Efficient Type-I Photodynamic Therapy. / Cui, Xiao (Co-first Author); Fang, Fang (Co-first Author); Chen, Huan (Co-first Author) et al.
In: Materials Horizons, Vol. 12, No. 3, 07.02.2025, p. 1002-1007.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

TY - JOUR

T1 - Using a Stable Radical as an “Electron Donor” to Develop a Radical Photosensitizer for Efficient Type-I Photodynamic Therapy

AU - Cui, Xiao

AU - Fang, Fang

AU - Chen, Huan

AU - Cao, Chen

AU - Xiao, Yafang

AU - Tian, Shuang

AU - Zhang, Jinfeng

AU - Li, Shengliang

AU - Lee, Chun Sing

PY - 2025/2/7

Y1 - 2025/2/7

N2 - Among type I photosensitizers, stable organic radicals are superior candidate molecules for hypoxia-overcoming photodynamic therapy. While their wide applications are limited by complicated preparation processes and poor stabilities. Herein, a nitroxide radical was simply synthesized by introducing a commercially available “TEMPO” moiety. The radical exhibit efficient type-I ROS generation, appreciable photo-cytotoxicity under hypoxia, which provides a new avenue into the exploration of novel and efficient type-I photosensitizer. © The Royal Society of Chemistry 2024

AB - Among type I photosensitizers, stable organic radicals are superior candidate molecules for hypoxia-overcoming photodynamic therapy. While their wide applications are limited by complicated preparation processes and poor stabilities. Herein, a nitroxide radical was simply synthesized by introducing a commercially available “TEMPO” moiety. The radical exhibit efficient type-I ROS generation, appreciable photo-cytotoxicity under hypoxia, which provides a new avenue into the exploration of novel and efficient type-I photosensitizer. © The Royal Society of Chemistry 2024

UR - http://www.scopus.com/inward/record.url?scp=85209761129&partnerID=8YFLogxK

UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-85209761129&origin=recordpage

U2 - 10.1039/D4MH00952E

DO - 10.1039/D4MH00952E

M3 - RGC 21 - Publication in refereed journal

SN - 2051-6347

VL - 12

SP - 1002

EP - 1007

JO - Materials Horizons

JF - Materials Horizons

IS - 3

ER -

Using a Stable Radical as an “Electron Donor” to Develop a Radical Photosensitizer for Efficient Type-I Photodynamic Therapy

Abstract

Funding

Publisher's Copyright Statement

RGC Funding Information

Access Output

Other Access Options

Permanent Link

Other Files and Links

Fingerprint

Cite this