Abstract
Rare earth-doped upconversion nanoparticles (UCNPs) have achieved a wide range of applications in the sensing field due to their unique anti-Stokes luminescence property, minimized background interference, excellent biocompatibility, and stable physicochemical properties. However, UCNPs-based sensing platforms still face several challenges, including inherent limitations from UCNPs such as low quantum yields and narrow absorption cross–sections, as well as constraints related to energy transfer efficiencies in sensing systems. Therefore, the construction of high-performance UCNPs-based sensing platforms is an important cornerstone for conducting relevant research. This work begins by providing a brief overview of the upconversion luminescence mechanism in UCNPs. Subsequently, it offers a comprehensive summary of the sensors’ types, design principles, and optimized design strategies for UCNPs sensing platforms. More cost-effective and promising point-of-care testing applications implemented based on UCNPs sensing systems are also summarized. Finally, this work addresses the future challenges and prospects for UCNPs-based sensing platforms. © 2024 Wiley-VCH GmbH.
| Original language | English |
|---|---|
| Article number | 2311729 |
| Journal | Small |
| Volume | 20 |
| Issue number | 29 |
| Online published | 28 Feb 2024 |
| DOIs | |
| Publication status | Published - 18 Jul 2024 |
Research Keywords
- energy transfer efficiency
- luminescence enhancement
- point-of-care testing
- sensing
- upconversion nanoparticles
Publisher's Copyright Statement
- COPYRIGHT TERMS OF DEPOSITED POSTPRINT FILE: This is the peer reviewed version of the following article: Wu, J., Wu, J., Wei, W., Zhang, Y., & Chen, Q. (2024). Upconversion Nanoparticles Based Sensing: From Design to Point-of-Care Testing. Small, 20(29), Article 2311729, which has been published in final form at https://doi.org/10.1002/smll.202311729. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.
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