Upconversion nanoparticles as versatile light nanotransducers for photoactivation applications

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

331 Scopus Citations
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Author(s)

  • Niagara Muhammad Idris
  • Muthu Kumara Gnanasammandhan Jayakumar
  • Akshaya Bansal
  • Yong Zhang

Detail(s)

Original languageEnglish
Pages (from-to)1449-1478
Journal / PublicationChemical Society Reviews
Volume44
Issue number6
Publication statusPublished - 21 Mar 2015
Externally publishedYes

Abstract

Remote activation of photoactivable therapeutic compounds by light provides a high spatial and temporal control for activating the therapeutic agent. However, photoactivable compounds are mostly responsive towards ultraviolet (UV) or visible light radiation that has poor tissue penetration depth besides being unsafe to the body in the case of UV light. Nanoparticles with energy upconversion hold potential in overcoming this limit by using safe and deeply penetrating near-infrared (NIR) light. These upconversion nanoparticles (UCNs) act as versatile nanotransducers as they convert NIR light to light of shorter wavelengths that can be tuned to the NIR, visible or UV colors to suit different activation wavelengths. Their highly unusual optical properties to fluoresce with near-zero photobleaching, photoblinking and background autofluorescence are unique and an added benefit when used simultaneously as optional imaging agents. This article reviews recent advancements in the use of UCNs for photoactivation of therapeutic agents. Specifically, we discuss the use of these UCNs for activation of light-sensitive/photocaged molecules or photosensitizers for photocontrolled-delivery and photodynamic therapy. This journal is © The Royal Society of Chemistry.

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Citation Format(s)

Upconversion nanoparticles as versatile light nanotransducers for photoactivation applications. / Idris, Niagara Muhammad; Jayakumar, Muthu Kumara Gnanasammandhan; Bansal, Akshaya et al.
In: Chemical Society Reviews, Vol. 44, No. 6, 21.03.2015, p. 1449-1478.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review