Upconversion-magnetic carbon sphere for near infrared light-triggered bioimaging and photothermal therapy

Jiaxin Wang; Chenjie Yao; Bin Shen; Xiaohui Zhu; Yong Li; Liyi Shi; Yong Zhang; Jinliang Liu; Yanli Wang; Lining Sun

doi:10.7150/thno.27952

Upconversion-magnetic carbon sphere for near infrared light-triggered bioimaging and photothermal therapy

Jiaxin Wang
, Chenjie Yao
, Bin Shen
, Xiaohui Zhu
, Yong Li
, Liyi Shi
, Yong Zhang
, Jinliang Liu^*
, Yanli Wang^*
, Lining Sun^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

52 Citations (Scopus)

33 Downloads (CityUHK Scholars)

Abstract

Nanoparticle-based theranostics combines tumor imaging and cancer therapy in one platform, but the synthesis of theranostic agents is impeded by chemical groups on the surface and the size and morphology of the components. Strategies to construct a multifunctional platform for bioimaging and photothermal therapy (PTT) are urgently needed. A new upconversion-magnetic agent (FeCUPs) based on hollow carbon spheres, which is both a photothermal agent and a dual carrier of luminescent and magnetic nanoparticles, provides an effective approach for tumor elimination.
Methods: The morphology of FeCUPs was characterized for the construction and size adjustment of the theranostic agent using transmission electron microscopy, high-resolution transmission electron microscopy, energy dispersive spectroscopy and high angle annular dark field scanning transmission electron microscopy. The distribution of FeCUPs was tracked under in-situ upconversion luminescence (UCL) imaging and magnetic resonance imaging (MRI) in vivo. Photothermal therapy was carried out on tumor-bearing mice, after which the toxicity of PTT was evaluated by a blood biochemistry test and histological section analysis.
Results: Stable and uniform loading of luminescent nanocomposites on three-dimensional carbon materials is reported for the first time. Based on the mechanism of synthesis, the size of the hybrid particles was adjusted from micrometers to nanometers. External magnetic field-enhanced photothermal therapy with multi-model imaging was accomplished using FeCUPs. Moreover, no cancer recurrence was found during 14 days of recovery without PTT.
Conclusions: Hollow carbon spheres, photothermal agents loaded with upconversion nanoparticles inside and magnetic nanoparticles outside were prepared for photothermal therapy. The aggregation of FeCUPs in tumors by the local magnetic field was verified by MRI and UCL imaging, and PTT was enhanced.
© 2018 Ivyspring International Publisher.

Original language	English
Pages (from-to)	608-619
Journal	Theranostics
Volume	9
Issue number	2
Online published	21 Jan 2019
DOIs	https://doi.org/10.7150/thno.27952
Publication status	Published - 2019
Externally published	Yes

Funding

We are grateful for the financial support from the National Natural Science Foundation of China (Grant Nos. 21571125, 31671011, 11575107), Medical Research Project of Jiangsu Provincial Commission of Health and Family Planning (NO. Z201624), and the National Key R&D Program of China (No. 2016YFE0114800).

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Keywords

Carbon
Hollow
Magnetic
Photothermal therapy
Upconversion

Publisher's Copyright Statement

This full text is made available under CC-BY-NC 4.0. https://creativecommons.org/licenses/by-nc/4.0/

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@article{5e100e307f9c42ef8fb2687a537b1677,

title = "Upconversion-magnetic carbon sphere for near infrared light-triggered bioimaging and photothermal therapy",

abstract = "Nanoparticle-based theranostics combines tumor imaging and cancer therapy in one platform, but the synthesis of theranostic agents is impeded by chemical groups on the surface and the size and morphology of the components. Strategies to construct a multifunctional platform for bioimaging and photothermal therapy (PTT) are urgently needed. A new upconversion-magnetic agent (FeCUPs) based on hollow carbon spheres, which is both a photothermal agent and a dual carrier of luminescent and magnetic nanoparticles, provides an effective approach for tumor elimination. Methods: The morphology of FeCUPs was characterized for the construction and size adjustment of the theranostic agent using transmission electron microscopy, high-resolution transmission electron microscopy, energy dispersive spectroscopy and high angle annular dark field scanning transmission electron microscopy. The distribution of FeCUPs was tracked under in-situ upconversion luminescence (UCL) imaging and magnetic resonance imaging (MRI) in vivo. Photothermal therapy was carried out on tumor-bearing mice, after which the toxicity of PTT was evaluated by a blood biochemistry test and histological section analysis. Results: Stable and uniform loading of luminescent nanocomposites on three-dimensional carbon materials is reported for the first time. Based on the mechanism of synthesis, the size of the hybrid particles was adjusted from micrometers to nanometers. External magnetic field-enhanced photothermal therapy with multi-model imaging was accomplished using FeCUPs. Moreover, no cancer recurrence was found during 14 days of recovery without PTT. Conclusions: Hollow carbon spheres, photothermal agents loaded with upconversion nanoparticles inside and magnetic nanoparticles outside were prepared for photothermal therapy. The aggregation of FeCUPs in tumors by the local magnetic field was verified by MRI and UCL imaging, and PTT was enhanced. {\textcopyright} 2018 Ivyspring International Publisher.",

keywords = "Carbon, Hollow, Magnetic, Photothermal therapy, Upconversion",

author = "Jiaxin Wang and Chenjie Yao and Bin Shen and Xiaohui Zhu and Yong Li and Liyi Shi and Yong Zhang and Jinliang Liu and Yanli Wang and Lining Sun",

year = "2019",

doi = "10.7150/thno.27952",

language = "English",

volume = "9",

pages = "608--619",

journal = "Theranostics",

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TY - JOUR

T1 - Upconversion-magnetic carbon sphere for near infrared light-triggered bioimaging and photothermal therapy

AU - Wang, Jiaxin

AU - Yao, Chenjie

AU - Shen, Bin

AU - Zhu, Xiaohui

AU - Li, Yong

AU - Shi, Liyi

AU - Zhang, Yong

AU - Liu, Jinliang

AU - Wang, Yanli

AU - Sun, Lining

PY - 2019

Y1 - 2019

N2 - Nanoparticle-based theranostics combines tumor imaging and cancer therapy in one platform, but the synthesis of theranostic agents is impeded by chemical groups on the surface and the size and morphology of the components. Strategies to construct a multifunctional platform for bioimaging and photothermal therapy (PTT) are urgently needed. A new upconversion-magnetic agent (FeCUPs) based on hollow carbon spheres, which is both a photothermal agent and a dual carrier of luminescent and magnetic nanoparticles, provides an effective approach for tumor elimination. Methods: The morphology of FeCUPs was characterized for the construction and size adjustment of the theranostic agent using transmission electron microscopy, high-resolution transmission electron microscopy, energy dispersive spectroscopy and high angle annular dark field scanning transmission electron microscopy. The distribution of FeCUPs was tracked under in-situ upconversion luminescence (UCL) imaging and magnetic resonance imaging (MRI) in vivo. Photothermal therapy was carried out on tumor-bearing mice, after which the toxicity of PTT was evaluated by a blood biochemistry test and histological section analysis. Results: Stable and uniform loading of luminescent nanocomposites on three-dimensional carbon materials is reported for the first time. Based on the mechanism of synthesis, the size of the hybrid particles was adjusted from micrometers to nanometers. External magnetic field-enhanced photothermal therapy with multi-model imaging was accomplished using FeCUPs. Moreover, no cancer recurrence was found during 14 days of recovery without PTT. Conclusions: Hollow carbon spheres, photothermal agents loaded with upconversion nanoparticles inside and magnetic nanoparticles outside were prepared for photothermal therapy. The aggregation of FeCUPs in tumors by the local magnetic field was verified by MRI and UCL imaging, and PTT was enhanced. © 2018 Ivyspring International Publisher.

AB - Nanoparticle-based theranostics combines tumor imaging and cancer therapy in one platform, but the synthesis of theranostic agents is impeded by chemical groups on the surface and the size and morphology of the components. Strategies to construct a multifunctional platform for bioimaging and photothermal therapy (PTT) are urgently needed. A new upconversion-magnetic agent (FeCUPs) based on hollow carbon spheres, which is both a photothermal agent and a dual carrier of luminescent and magnetic nanoparticles, provides an effective approach for tumor elimination. Methods: The morphology of FeCUPs was characterized for the construction and size adjustment of the theranostic agent using transmission electron microscopy, high-resolution transmission electron microscopy, energy dispersive spectroscopy and high angle annular dark field scanning transmission electron microscopy. The distribution of FeCUPs was tracked under in-situ upconversion luminescence (UCL) imaging and magnetic resonance imaging (MRI) in vivo. Photothermal therapy was carried out on tumor-bearing mice, after which the toxicity of PTT was evaluated by a blood biochemistry test and histological section analysis. Results: Stable and uniform loading of luminescent nanocomposites on three-dimensional carbon materials is reported for the first time. Based on the mechanism of synthesis, the size of the hybrid particles was adjusted from micrometers to nanometers. External magnetic field-enhanced photothermal therapy with multi-model imaging was accomplished using FeCUPs. Moreover, no cancer recurrence was found during 14 days of recovery without PTT. Conclusions: Hollow carbon spheres, photothermal agents loaded with upconversion nanoparticles inside and magnetic nanoparticles outside were prepared for photothermal therapy. The aggregation of FeCUPs in tumors by the local magnetic field was verified by MRI and UCL imaging, and PTT was enhanced. © 2018 Ivyspring International Publisher.

KW - Carbon

KW - Hollow

KW - Magnetic

KW - Photothermal therapy

KW - Upconversion

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U2 - 10.7150/thno.27952

DO - 10.7150/thno.27952

M3 - RGC 21 - Publication in refereed journal

C2 - 30809296

SN - 1838-7640

VL - 9

SP - 608

EP - 619

JO - Theranostics

JF - Theranostics

IS - 2

ER -

Upconversion-magnetic carbon sphere for near infrared light-triggered bioimaging and photothermal therapy

Abstract

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Research Keywords

Publisher's Copyright Statement

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