目的: 研究我国药用植物类叶升麻 Actaea asiatica 根茎的化学成分,为阐明其有效成分提供依据。方法:利用硅胶柱色谱,反相柱色谱,半制备液相进行分离,根据化合物的光谱数据 (IR,MS,1H-NMR,13C-NMR) 和化学方法鉴定其结构。结果:从根茎的醋酸乙酯萃取物中分离得到6 个化合物,分别鉴定为25-O-乙酰升麻醇(1),12β-羟基升麻醇(2),23-epi-26-deoxyactein ( 3), 27-deoxyacetylacteol (4), 26-deoxycimicifugenin (5) 及β-谷甾醇(6)。结论: 以上化合物均为首次从该属植物中分离得到。

Objective: To investigate the chemical constituents of the rhizomes of Actaea asiatica in order to obtain a more comprehensive understanding of its effective components. Method: Compounds were separated by silica gel chromatography, RP-C18 chromatography and semi-preparative high performance liquid chromatography, and their structures were established by spectral analysis and chemical evidence. Result: Six compounds were isolated from the ethyl acetate extract. Their structures were identified as 25-O-acetylcimigenol (1), 12β-hydroxycimigenol (2), 23-epi-26-deoxyactein (3), 27-deoxyacetylacteol (4), 26-deoxycimicifugenin (5) and β-sitosterol (6). Conclusion: All these compounds mentioned above were isolated from the plant for the first time.