Unsymmetrical β-cyclodextrin-conjugated silicon(iv) phthalocyanines as highly potent photosensitisers for photodynamic therapy

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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  • Janet T. F. Lau
  • Pui-Chi Lo
  • Yee-Man Tsang
  • Wing-Ping Fong
  • Dennis K. P. Ng


Original languageEnglish
Pages (from-to)9657-9659
Journal / PublicationChemical Communications
Issue number34
Publication statusPublished - 14 Sept 2011
Externally publishedYes


A series of unsymmetrical silicon(iv) phthalocyanines with a permethylated β-cyclodextrin unit and a sugar or a diamino moiety as the axial substituents have been prepared. These compounds are highly photocytotoxic with IC 50 values as low as 21 nM, which is ca. sevenfold lower than those of the symmetrical bis(cyclodextrin) analogue. © The Royal Society of Chemistry 2011.

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