Unsymmetrical β-cyclodextrin-conjugated silicon(iv) phthalocyanines as highly potent photosensitisers for photodynamic therapy

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

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Author(s)

  • Janet T. F. Lau
  • Pui-Chi Lo
  • Yee-Man Tsang
  • Wing-Ping Fong
  • Dennis K. P. Ng

Detail(s)

Original languageEnglish
Pages (from-to)9657-9659
Journal / PublicationChemical Communications
Volume47
Issue number34
Publication statusPublished - 14 Sep 2011
Externally publishedYes

Abstract

A series of unsymmetrical silicon(iv) phthalocyanines with a permethylated β-cyclodextrin unit and a sugar or a diamino moiety as the axial substituents have been prepared. These compounds are highly photocytotoxic with IC 50 values as low as 21 nM, which is ca. sevenfold lower than those of the symmetrical bis(cyclodextrin) analogue. © The Royal Society of Chemistry 2011.

Citation Format(s)

Unsymmetrical β-cyclodextrin-conjugated silicon(iv) phthalocyanines as highly potent photosensitisers for photodynamic therapy. / Lau, Janet T. F.; Lo, Pui-Chi; Tsang, Yee-Man; Fong, Wing-Ping; Ng, Dennis K. P.

In: Chemical Communications, Vol. 47, No. 34, 14.09.2011, p. 9657-9659.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal