Unraveling the Fungal Strategy for Tetrahydroxanthone Biosynthesis and Diversification

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

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Original languageEnglish
Pages (from-to)1919−1923
Journal / PublicationOrganic Letters
Volume22
Issue number5
Online published27 Feb 2020
Publication statusPublished - 6 Mar 2020

Abstract

In vivo and in vitro reconstitution of the biosynthesis of fungal tetrahydroxanthones (THXs), blennolides A and C, led to the identification and characterization of the key enzymes for THX biosynthesis and diversification. The unusual isomerase NsrQ plays a crucial role in the THX skeleton synthesis probably by catalyzing the 1,2- hydride shift and methyl group epimerization, thus allowing dearomatizing cyclization to provide the THX architecture.