Unraveling the Fungal Strategy for Tetrahydroxanthone Biosynthesis and Diversification

Xingxing Wei; Yudai Matsuda

doi:10.1021/acs.orglett.0c00285

Unraveling the Fungal Strategy for Tetrahydroxanthone Biosynthesis and Diversification

Xingxing Wei, Yudai Matsuda^*

^*Corresponding author for this work

Department of Chemistry

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

29 Citations (Scopus)

39 Downloads (CityUHK Scholars)

Abstract

In vivo and in vitro reconstitution of the biosynthesis of fungal tetrahydroxanthones (THXs), blennolides A and C, led to the identification and characterization of the key enzymes for THX biosynthesis and diversification. The unusual isomerase NsrQ plays a crucial role in the THX skeleton synthesis probably by catalyzing the 1,2- hydride shift and methyl group epimerization, thus allowing dearomatizing cyclization to provide the THX architecture.

Original language	English
Pages (from-to)	1919−1923
Journal	Organic Letters
Volume	22
Issue number	5
Online published	27 Feb 2020
DOIs	https://doi.org/10.1021/acs.orglett.0c00285
Publication status	Published - 6 Mar 2020

Publisher's Copyright Statement

COPYRIGHT TERMS OF DEPOSITED POSTPRINT FILE: This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, copyright © 2020 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.orglett.0c00285.

Access Output

10.1021/acs.orglett.0c00285

44032621.pdfPost-print, 1.36 MB

Other Access Options

Check CityUHK Library

Permanent Link

Right click to copy link

Cite this

@article{2c85e2f9bc3b44d587d1ac9b534d3d22,

title = "Unraveling the Fungal Strategy for Tetrahydroxanthone Biosynthesis and Diversification",

abstract = "In vivo and in vitro reconstitution of the biosynthesis of fungal tetrahydroxanthones (THXs), blennolides A and C, led to the identification and characterization of the key enzymes for THX biosynthesis and diversification. The unusual isomerase NsrQ plays a crucial role in the THX skeleton synthesis probably by catalyzing the 1,2- hydride shift and methyl group epimerization, thus allowing dearomatizing cyclization to provide the THX architecture.",

author = "Xingxing Wei and Yudai Matsuda",

year = "2020",

month = mar,

day = "6",

doi = "10.1021/acs.orglett.0c00285",

language = "English",

volume = "22",

pages = "1919−1923",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

number = "5",

}

TY - JOUR

T1 - Unraveling the Fungal Strategy for Tetrahydroxanthone Biosynthesis and Diversification

AU - Wei, Xingxing

AU - Matsuda, Yudai

PY - 2020/3/6

Y1 - 2020/3/6

N2 - In vivo and in vitro reconstitution of the biosynthesis of fungal tetrahydroxanthones (THXs), blennolides A and C, led to the identification and characterization of the key enzymes for THX biosynthesis and diversification. The unusual isomerase NsrQ plays a crucial role in the THX skeleton synthesis probably by catalyzing the 1,2- hydride shift and methyl group epimerization, thus allowing dearomatizing cyclization to provide the THX architecture.

AB - In vivo and in vitro reconstitution of the biosynthesis of fungal tetrahydroxanthones (THXs), blennolides A and C, led to the identification and characterization of the key enzymes for THX biosynthesis and diversification. The unusual isomerase NsrQ plays a crucial role in the THX skeleton synthesis probably by catalyzing the 1,2- hydride shift and methyl group epimerization, thus allowing dearomatizing cyclization to provide the THX architecture.

UR - http://www.scopus.com/inward/record.url?scp=85081944452&partnerID=8YFLogxK

UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-85081944452&origin=recordpage

U2 - 10.1021/acs.orglett.0c00285

DO - 10.1021/acs.orglett.0c00285

M3 - RGC 21 - Publication in refereed journal

C2 - 32105084

SN - 1523-7060

VL - 22

SP - 1919−1923

JO - Organic Letters

JF - Organic Letters

IS - 5

ER -

Unraveling the Fungal Strategy for Tetrahydroxanthone Biosynthesis and Diversification

Abstract

Publisher's Copyright Statement

Access Output

Other Access Options

Permanent Link

Other Files and Links

Fingerprint

ECS: Comprehensive Understanding and Engineering of Fungal Xanthone Biosynthesis

Cite this

Unraveling the Fungal Strategy for Tetrahydroxanthone Biosynthesis and Diversification

Abstract

Publisher's Copyright Statement

Access Output

Other Access Options

Permanent Link

Other Files and Links

Fingerprint

Projects

ECS: Comprehensive Understanding and Engineering of Fungal Xanthone Biosynthesis

Cite this