Uniquely Hominid Features of Adult Human Astrocytes

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

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Author(s)

  • Nancy Ann Oberheim
  • Takahiro Takano
  • Xiaoning Han
  • Wei He
  • Jane H. C. Lin
  • Fushun Wang
  • Qiwu Xu
  • Jeffrey D. Wyatt
  • Webster Pilcher
  • Jeffrey G. Ojemann
  • Steven A. Goldman
  • Maiken Nedergaard

Detail(s)

Original languageEnglish
Pages (from-to)3276-3287
Journal / PublicationJournal of Neuroscience
Volume29
Issue number10
Publication statusPublished - 11 Mar 2009
Externally publishedYes

Abstract

Defining the microanatomic differences between the human brain and that of other mammals is key to understanding its unique computational power. Although much effort has been devoted to comparative studies of neurons, astrocytes have received far less attention. We report here that protoplasmic astrocytes in human neocortex are 2.6-fold larger in diameter and extend 10-fold more GFAP (glial fibrillary acidic protein)-positive primary processes than their rodent counterparts. In cortical slices prepared from acutely resected surgical tissue, protoplasmic astrocytes propagate Ca2+ waves with a speed of 36 μm/s, approximately fourfold faster than rodent. Human astrocytes also transiently increase cystosolic Ca2+ in response to glutamatergic and purinergic receptor agonists. The human neocortex also harbors several anatomically defined subclasses of astrocytes not represented in rodents. These include a population of astrocytes that reside in layers 5-6 and extend long fibers characterized by regularly spaced varicosities. Another specialized type of astrocyte, the interlaminar astrocyte, abundantly populates the superficial cortical layers and extends long processes without varicosities to cortical layers 3 and 4. Human fibrous astrocytes resemble their rodent counterpart but are larger in diameter. Thus, human cortical astrocytes are both larger, and structurally both more complex and more diverse, than those of rodents. On this basis, we posit that this astrocytic complexity has permitted the increased functional competence of the adult human brain. Copyright © 2009 Society for Neuroscience.

Citation Format(s)

Uniquely Hominid Features of Adult Human Astrocytes. / Oberheim, Nancy Ann; Takano, Takahiro; Han, Xiaoning; He, Wei; Lin, Jane H. C.; Wang, Fushun; Xu, Qiwu; Wyatt, Jeffrey D.; Pilcher, Webster; Ojemann, Jeffrey G.; Ransom, Bruce R.; Goldman, Steven A.; Nedergaard, Maiken.

In: Journal of Neuroscience, Vol. 29, No. 10, 11.03.2009, p. 3276-3287.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal