Unique Role of Arginine in Positively-Charged Surface for Promotion of Antibacterial and Osteogenetic Capabilities

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalNot applicablepeer-review

View graph of relations

Author(s)

  • Wei Zhang
  • Jun Liu
  • Kun Yang
  • Wei Qu
  • Ke Liu
  • Na Liu
  • Bin Gu
  • Nan Hu
  • Junhui Ji
  • Huaiyu Wang

Detail(s)

Original languageEnglish
Article number1901414
Journal / PublicationAdvanced Materials Interfaces
Volume6
Issue number23
Online published14 Oct 2019
Publication statusPublished - 6 Dec 2019

Abstract

Orthopedic implants made of titanium and titanium alloys are vulnerable to invasion of pathogenic bacteria and hence, it is desirable to endow implants with the antibacterial capability to mitigate postsurgical infection and other undesirable side-effects. In this study, arginine is combined with polyhexamethylene biguaidine hydrochloride (PHMB) to fabricate an antibacterial coating on titanium samples. As arginine with the guanidinium form is similar to PHMB, the coating is positively-charged and delivers excellent antibacterial performance due to the high surface potential. Furthermore, arginine is a natural alpha-amino acid being friendlier to tissues than PHMB and the coating delivers good osteogenetic performance in vitro and in vivo in addition to a low level of inflammatory response. The combination of cationic arginine and PHMB enhances the antibacterial and osteogenetic functions simultaneously and suggests clinical potential.

Research Area(s)

  • antibacterial properties, arginine, osteogenic capabilities, positively-charged surface, titanium inplant, POLYHEXAMETHYLENE GUANIDINE-HYDROCHLORIDE, MOLECULAR-MECHANISMS, BIOFILM FORMATION, TITANIUM, OSSEOINTEGRATION, BIOCOMPATIBILITY, CYTOTOXICITY, TOLERANCE, COATINGS

Citation Format(s)

Unique Role of Arginine in Positively-Charged Surface for Promotion of Antibacterial and Osteogenetic Capabilities. / Zhang, Wei; Liu, Jun; Yang, Kun; Qu, Wei; Liu, Ke; Liu, Na; Gu, Bin; Hu, Nan; Ji, Junhui; Chu, Paul K.; Wang, Huaiyu.

In: Advanced Materials Interfaces, Vol. 6, No. 23, 1901414, 06.12.2019.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalNot applicablepeer-review