Ultrathin, Soft, Bioresorbable Organic Electrochemical Transistors for Transient Spatiotemporal Mapping of Brain Activity
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
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Detail(s)
Original language | English |
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Article number | 2300504 |
Journal / Publication | Advanced Science |
Volume | 5 |
Issue number | 17 |
Online published | 24 Feb 2023 |
Publication status | Published - 17 May 2023 |
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DOI | DOI |
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Document Link | |
Link to Scopus | https://www.scopus.com/record/display.uri?eid=2-s2.0-85148725217&origin=recordpage |
Permanent Link | https://scholars.cityu.edu.hk/en/publications/publication(7160c3c4-3272-4531-af00-996da409bf30).html |
Abstract
A critical challenge lies in the development of the next-generation neural interface, in mechanically tissue-compatible fashion, that offer accurate, transient recording electrophysiological (EP) information and autonomous degradation after stable operation. Here, an ultrathin, lightweight, soft and multichannel neural interface is presented based on organic-electrochemical-transistor-(OECT)-based network, with capabilities of continuous high-fidelity mapping of neural signals and biosafety active degrading after performing functions. Such platform yields a high spatiotemporal resolution of 1.42 ms and 20 µm, with signal-to-noise ratio up to ≈37 dB. The implantable OECT arrays can well establish stable functional neural interfaces, designed as fully biodegradable electronic platforms in vivo. Demonstrated applications of such OECT implants include real-time monitoring of electrical activities from the cortical surface of rats under various conditions (e.g., narcosis, epileptic seizure, and electric stimuli) and electrocorticography mapping from 100 channels. This technology offers general applicability in neural interfaces, with great potential utility in treatment/diagnosis of neurological disorders. © 2023 The Authors. Advanced Science published by Wiley-VCH GmbH.
Research Area(s)
- bioresorbable materials, multichannel electrophysiology mapping, neural interfaces, organic electrochemical transistor, transient electronics
Citation Format(s)
Ultrathin, Soft, Bioresorbable Organic Electrochemical Transistors for Transient Spatiotemporal Mapping of Brain Activity. / Wu, Mengge; Yao, Kuanming; Huang, Ningge et al.
In: Advanced Science, Vol. 5, No. 17, 2300504, 17.05.2023.
In: Advanced Science, Vol. 5, No. 17, 2300504, 17.05.2023.
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
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