Ultrathin CuFe2S3 nanosheets derived from CuFe-layered double hydroxide as an efficient nanoagent for synergistic chemodynamic and NIR-II photothermal therapy

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Sa Wang
  • Tingting Hu
  • Guanyun Wang
  • Zhengdi Wang
  • Dan Yan
  • Ruizheng Liang

Related Research Unit(s)

Detail(s)

Original languageEnglish
Article number129458
Journal / PublicationChemical Engineering Journal
Volume419
Online published29 Mar 2021
Publication statusPublished - 1 Sep 2021

Abstract

Ultrathin two-dimensional (2D) nanosheets (NSs) have been widely explored as nanoagents for multimodal cancer therapies, such as photothermal therapy (PTT) combined with chemodynamic therapy (CDT). However, it is still a challenge to prepare 2D NSs with good performance in both CDT and NIR-II PTT. Here, we report the preparation of ultrathin 2D CuFe2S3 NSs as an efficient nanoagent for synergistic CDT and NIR-II PTT to ablate cancer cells/tumors. Ultrathin 2D CuFe2S3 NSs are first prepared by sulfurization of ultrathin CuFe-LDH NSs via a simple hydrothermal treatment. After modification with polyethylene glycol (PEG), the PEG-modified CuFe2S3 NSs (CuFe2S3-PEG) show broadband NIR-II absorption and excellent photothermal conversion efficiency (~55.86%) at 1064 nm. Moreover, the overproduced glutathione in the tumor microenvironment can react with CuFe2S3-PEG NSs to release Fe2+ and Cu+, thus activating Fenton reaction to efficiently produce hydroxyl radicals (·OH). Importantly, the photothermal effect of CuFe2S3-PEG could further synergistically improve the Fenton reaction by increasing the local temperature. In vitro and in vivo results reveal that the CuFe2S3-PEG has remarkable synergistic CDT/PTT antitumor activity. This study has proven that the metal chalcogenide NSs of CuFe2S3-PEG can be used as an efficient nanoagent for multimodal cancer therapies, which could also be promising in other applications like biosensors, drug delivery and antibacterial.

Research Area(s)

  • Chemodynamic therapy, CuFe2S3 nanosheets, NIR-II photothermal therapy, Synergistic therapy

Citation Format(s)

Ultrathin CuFe2S3 nanosheets derived from CuFe-layered double hydroxide as an efficient nanoagent for synergistic chemodynamic and NIR-II photothermal therapy. / Wang, Sa; Hu, Tingting; Wang, Guanyun; Wang, Zhengdi; Yan, Dan; Liang, Ruizheng; Tan, Chaoliang.

In: Chemical Engineering Journal, Vol. 419, 129458, 01.09.2021.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review