Ultrasound-heated photoacoustic flowmetry

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

17 Scopus Citations
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Author(s)

  • Lidai Wang
  • Junjie Yao
  • Konstantin I. Maslov
  • Wenxin Xing
  • Lihong V. Wang

Detail(s)

Original languageEnglish
Article number117003
Journal / PublicationJournal of Biomedical Optics
Volume18
Issue number11
Publication statusPublished - Nov 2013
Externally publishedYes

Abstract

We report the development of photoacoustic flowmetry assisted by high-intensity focused ultrasound (HIFU). This novel method employs HIFU to generate a heating impulse in the flow medium, followed by photoacoustic monitoring of the thermal decay process. Photoacoustic flowmetry in a continuous medium remains a challenge in the optical diffusive regime. Here, both the HIFU heating and photoacoustic detection can focus at depths beyond the optical diffusion limit (~1 mm in soft tissue). This method can be applied to a continuous medium, i.e., a medium without discrete scatterers or absorbers resolvable by photoacoustic imaging. Flow speeds up to 41 mm • s -1 have been experimentally measured in a blood phantom covered by 1.5-mm-thick tissue. © 2013 Society of Photo-Optical Instrumentation Engineers.

Research Area(s)

  • deep imaging, flow, high-intensity focused ultrasound, photoacoustic microscopy, thermal clearance

Citation Format(s)

Ultrasound-heated photoacoustic flowmetry. / Wang, Lidai; Yao, Junjie; Maslov, Konstantin I. et al.
In: Journal of Biomedical Optics, Vol. 18, No. 11, 117003, 11.2013.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review