Ultrasound-enhanced precision tumor theranostics using cell membrane-coated and pH-responsive nanoclusters assembled from ultrasmall iron oxide nanoparticles

Liang Jia; Xin Li; Hui Liu; Jindong Xia; Xiangyang Shi; Mingwu Shen

doi:10.1016/j.nantod.2020.101022

Ultrasound-enhanced precision tumor theranostics using cell membrane-coated and pH-responsive nanoclusters assembled from ultrasmall iron oxide nanoparticles

Liang Jia
, Xin Li
, Hui Liu
, Jindong Xia
, Xiangyang Shi^*
, Mingwu Shen^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

120 Citations (Scopus)

Abstract

Design of novel theranostic nanoplatforms integrating precision dynamic imaging modalities, tumor targeting ligands and therapeutic components with enhanced tumor accumulation still remains to be challenging. Here we report a facile strategy to prepare cell membrane (CM)-coated nanoclusters assembled from ultrasmall iron oxide nanoparticles (USIO NPs) with pH-responsiveness as a nanocarrier to load anti-cancer drug doxorubicin (DOX). Citric-stabilized USIO NPs with a size of 3.2 nm were synthesized, modified to have surface amine groups, and crosslinked to obtain pH-responsive nanoclusters (NCs). Then, the formed USIO NCs were loaded with DOX, and coated with cancer CMs to render them with resistance to macrophage cellular uptake and homologous cancer cell targeting specificity. Within the acidic tumor microenvironment, the pH-responsive USIO NCs/DOX@CM with dominant T₂ magnetic resonance (MR) imaging performance can be dissociated to form single USIO NPs with T₁ MR imaging ability, and simultaneously rapidly release DOX, thereby enabling dynamic T₂/T₁-weighted MR imaging and chemotherapy of tumors. Further, through the ultrasound-induced sonoporation effect, the dynamic MR imaging and tumor chemotherapy can be further enhanced. The designed USIO NCs/DOX@CM may be developed as a versatile theranostic platform for ultrasound-enhanced targeted precision theranostics of different cancer types.

Original language	English
Article number	101022
Journal	Nano Today
Volume	36
Online published	10 Nov 2020
DOIs	https://doi.org/10.1016/j.nantod.2020.101022
Publication status	Published - Feb 2021
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2020 Elsevier Ltd

Funding

This research has been financially supported by the Sino-German Center for Research Promotion (GZ1505), the National Natural Science Foundation of China (81761148028), the Science and Technology Commission of Shanghai Municipality (19410740200 and 19XD1400100), and the China Scholarship Council (for X. Li). X. Shi also thanks the support by FCT-Fundação para a Ciência e a Tecnologia through the CQM Base Fund - UIDB/00674/2020, and Programmatic Fund - UIDP/00674/2020, and by ARDITI-Agência Regional para o Desenvolvimento da Investigação Tecnologia e Inovação, through the project M1420-01-0145-FEDER-000005 - Centro de Química da Madeira - CQM+ (Madeira 14-20 Program).

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Keywords

Cell membrane
Chemotherapy
Dynamic MR imaging
Iron oxide nanoclusters
pH responsiveness

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10.1016/j.nantod.2020.101022

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title = "Ultrasound-enhanced precision tumor theranostics using cell membrane-coated and pH-responsive nanoclusters assembled from ultrasmall iron oxide nanoparticles",

abstract = "Design of novel theranostic nanoplatforms integrating precision dynamic imaging modalities, tumor targeting ligands and therapeutic components with enhanced tumor accumulation still remains to be challenging. Here we report a facile strategy to prepare cell membrane (CM)-coated nanoclusters assembled from ultrasmall iron oxide nanoparticles (USIO NPs) with pH-responsiveness as a nanocarrier to load anti-cancer drug doxorubicin (DOX). Citric-stabilized USIO NPs with a size of 3.2 nm were synthesized, modified to have surface amine groups, and crosslinked to obtain pH-responsive nanoclusters (NCs). Then, the formed USIO NCs were loaded with DOX, and coated with cancer CMs to render them with resistance to macrophage cellular uptake and homologous cancer cell targeting specificity. Within the acidic tumor microenvironment, the pH-responsive USIO NCs/DOX@CM with dominant T2 magnetic resonance (MR) imaging performance can be dissociated to form single USIO NPs with T1 MR imaging ability, and simultaneously rapidly release DOX, thereby enabling dynamic T2/T1-weighted MR imaging and chemotherapy of tumors. Further, through the ultrasound-induced sonoporation effect, the dynamic MR imaging and tumor chemotherapy can be further enhanced. The designed USIO NCs/DOX@CM may be developed as a versatile theranostic platform for ultrasound-enhanced targeted precision theranostics of different cancer types.{\textcopyright} 2020 Elsevier Ltd.",

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author = "Liang Jia and Xin Li and Hui Liu and Jindong Xia and Xiangyang Shi and Mingwu Shen",

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doi = "10.1016/j.nantod.2020.101022",

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T1 - Ultrasound-enhanced precision tumor theranostics using cell membrane-coated and pH-responsive nanoclusters assembled from ultrasmall iron oxide nanoparticles

AU - Jia, Liang

AU - Li, Xin

AU - Liu, Hui

AU - Xia, Jindong

AU - Shi, Xiangyang

AU - Shen, Mingwu

PY - 2021/2

Y1 - 2021/2

N2 - Design of novel theranostic nanoplatforms integrating precision dynamic imaging modalities, tumor targeting ligands and therapeutic components with enhanced tumor accumulation still remains to be challenging. Here we report a facile strategy to prepare cell membrane (CM)-coated nanoclusters assembled from ultrasmall iron oxide nanoparticles (USIO NPs) with pH-responsiveness as a nanocarrier to load anti-cancer drug doxorubicin (DOX). Citric-stabilized USIO NPs with a size of 3.2 nm were synthesized, modified to have surface amine groups, and crosslinked to obtain pH-responsive nanoclusters (NCs). Then, the formed USIO NCs were loaded with DOX, and coated with cancer CMs to render them with resistance to macrophage cellular uptake and homologous cancer cell targeting specificity. Within the acidic tumor microenvironment, the pH-responsive USIO NCs/DOX@CM with dominant T2 magnetic resonance (MR) imaging performance can be dissociated to form single USIO NPs with T1 MR imaging ability, and simultaneously rapidly release DOX, thereby enabling dynamic T2/T1-weighted MR imaging and chemotherapy of tumors. Further, through the ultrasound-induced sonoporation effect, the dynamic MR imaging and tumor chemotherapy can be further enhanced. The designed USIO NCs/DOX@CM may be developed as a versatile theranostic platform for ultrasound-enhanced targeted precision theranostics of different cancer types.© 2020 Elsevier Ltd.

AB - Design of novel theranostic nanoplatforms integrating precision dynamic imaging modalities, tumor targeting ligands and therapeutic components with enhanced tumor accumulation still remains to be challenging. Here we report a facile strategy to prepare cell membrane (CM)-coated nanoclusters assembled from ultrasmall iron oxide nanoparticles (USIO NPs) with pH-responsiveness as a nanocarrier to load anti-cancer drug doxorubicin (DOX). Citric-stabilized USIO NPs with a size of 3.2 nm were synthesized, modified to have surface amine groups, and crosslinked to obtain pH-responsive nanoclusters (NCs). Then, the formed USIO NCs were loaded with DOX, and coated with cancer CMs to render them with resistance to macrophage cellular uptake and homologous cancer cell targeting specificity. Within the acidic tumor microenvironment, the pH-responsive USIO NCs/DOX@CM with dominant T2 magnetic resonance (MR) imaging performance can be dissociated to form single USIO NPs with T1 MR imaging ability, and simultaneously rapidly release DOX, thereby enabling dynamic T2/T1-weighted MR imaging and chemotherapy of tumors. Further, through the ultrasound-induced sonoporation effect, the dynamic MR imaging and tumor chemotherapy can be further enhanced. The designed USIO NCs/DOX@CM may be developed as a versatile theranostic platform for ultrasound-enhanced targeted precision theranostics of different cancer types.© 2020 Elsevier Ltd.

KW - Cell membrane

KW - Chemotherapy

KW - Dynamic MR imaging

KW - Iron oxide nanoclusters

KW - pH responsiveness

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ER -

Ultrasound-enhanced precision tumor theranostics using cell membrane-coated and pH-responsive nanoclusters assembled from ultrasmall iron oxide nanoparticles

Abstract

Bibliographical note

Funding

UN SDGs

Research Keywords

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