Ultrasonically encoded photoacoustic flowgraphy in biological tissue

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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Author(s)

  • Lidai Wang
  • Jun Xia
  • Junjie Yao
  • Konstantin I. Maslov
  • Lihong V. Wang

Detail(s)

Original languageEnglish
Article number204301
Journal / PublicationPhysical Review Letters
Volume111
Issue number20
Online published12 Nov 2013
Publication statusPublished - 15 Nov 2013
Externally publishedYes

Abstract

Blood flow speed is an important functional parameter. Doppler ultrasound flowmetry lacks sufficient sensitivity to slow blood flow (several to tens of millimeters per second) in deep tissue. To address this challenge, we developed ultrasonically encoded photoacoustic flowgraphy combining ultrasonic thermal tagging with photoacoustic imaging. Focused ultrasound generates a confined heat source in acoustically absorptive fluid. Thermal waves propagate with the flow and are directly visualized in pseudo color using photoacoustic computed tomography. The Doppler shift is employed to calculate the flow speed. This method requires only acoustic and optical absorption, and thus is applicable to continuous fluid. A blood flow speed as low as 0.24 mm·s-1 was successfully measured. Deep blood flow imaging was experimentally demonstrated under 5-mm-thick chicken breast tissue. © 2013 American Physical Society.

Citation Format(s)

Ultrasonically encoded photoacoustic flowgraphy in biological tissue. / Wang, Lidai; Xia, Jun; Yao, Junjie et al.
In: Physical Review Letters, Vol. 111, No. 20, 204301, 15.11.2013.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review