Ultrasensitive Profiling of Metabolites Using Tyramine-Functionalized Graphene Quantum Dots

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Nan Li
  • Aung Than
  • Xuewan Wang
  • Shaohai Xu
  • Lei Sun
  • Hongwei Duan
  • Peng Chen

Detail(s)

Original languageEnglish
Pages (from-to)3622-3629
Journal / PublicationACS Nano
Volume10
Issue number3
Online published3 Mar 2016
Publication statusPublished - 22 Mar 2016
Externally publishedYes

Abstract

Graphene quantum dots (GQDs) are emerging fluorescence reporters attractive for optical sensing, owing to their high photostability, highly tunable photoluminescence, molecular size, atomically thin structure, biocompatibility, and ease of functionalization. Herein, we present a fluorometric sensing platform based on tyramine-functionalized GQDs, which is able to detect a spectrum of metabolites with high sensitivity and specificity. Furthermore, multiparametric blood analysis (glucose, cholesterol, l-lactate, and xanthine) is demonstrated. This convenient metabolite profiling technique could be instrumental for diagnosis, study, and management of metabolic disorders and associated diseases, such as diabetes, obesity, lactic acidosis, gout, and hypertension.

Research Area(s)

  • graphene quantum dots, fluorometric biosensing, photoluminescence quenching, metabolite detection

Citation Format(s)

Ultrasensitive Profiling of Metabolites Using Tyramine-Functionalized Graphene Quantum Dots. / Li, Nan; Than, Aung; Wang, Xuewan et al.

In: ACS Nano, Vol. 10, No. 3, 22.03.2016, p. 3622-3629.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review