Ultrasensitive Profiling of Metabolites Using Tyramine-Functionalized Graphene Quantum Dots
Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review
Author(s)
Detail(s)
| Original language | English |
|---|---|
| Pages (from-to) | 3622-3629 |
| Journal / Publication | ACS Nano |
| Volume | 10 |
| Issue number | 3 |
| Online published | 3 Mar 2016 |
| Publication status | Published - 22 Mar 2016 |
| Externally published | Yes |
Link(s)
Abstract
Graphene quantum dots (GQDs) are emerging fluorescence reporters attractive for optical sensing, owing to their high photostability, highly tunable photoluminescence, molecular size, atomically thin structure, biocompatibility, and ease of functionalization. Herein, we present a fluorometric sensing platform based on tyramine-functionalized GQDs, which is able to detect a spectrum of metabolites with high sensitivity and specificity. Furthermore, multiparametric blood analysis (glucose, cholesterol, l-lactate, and xanthine) is demonstrated. This convenient metabolite profiling technique could be instrumental for diagnosis, study, and management of metabolic disorders and associated diseases, such as diabetes, obesity, lactic acidosis, gout, and hypertension.
Research Area(s)
- graphene quantum dots, fluorometric biosensing, photoluminescence quenching, metabolite detection
Citation Format(s)
Ultrasensitive Profiling of Metabolites Using Tyramine-Functionalized Graphene Quantum Dots. / Li, Nan; Than, Aung; Wang, Xuewan et al.
In: ACS Nano, Vol. 10, No. 3, 22.03.2016, p. 3622-3629.Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review
