Ultra-sensitive fluorescent probes for hypochlorite acid detection and exogenous/endogenous imaging of living cells

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalNot applicablepeer-review

17 Scopus Citations
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Author(s)

  • Yin Jiang
  • Guansheng Zheng
  • Qinya Duan
  • Jie Zhang
  • Huatang Zhang
  • Jun He

Detail(s)

Original languageEnglish
Pages (from-to)7967-7970
Journal / PublicationChemical Communications
Volume54
Issue number57
Online published20 Jun 2018
Publication statusPublished - 21 Jul 2018

Abstract

Two fluorescent probes (Naph-1 and Naph-2), which can be prepared via a facile process, have been developed to detect hypochlorite acid (HOCl). The N,N-dimethyl thiocarbamate group quenches the fluorescence of the probes through intramolecular charge transfer (ICT). Upon reaction with HOCl in aqueous buffer, Naph-1 shows ultra-high sensitivity towards HOCl through a 4600-fold increase in fluorescence intensity, as well as a detection limit of 2.37 nM. The probes have been applied to confocal fluorescence imaging of exogenous and endogenous HOCl in living cells.

Citation Format(s)

Ultra-sensitive fluorescent probes for hypochlorite acid detection and exogenous/endogenous imaging of living cells. / Jiang, Yin; Zheng, Guansheng; Duan, Qinya; Yang, Liu; Zhang, Jie; Zhang, Huatang; He, Jun; Sun, Hongyan; Ho, Derek.

In: Chemical Communications, Vol. 54, No. 57, 21.07.2018, p. 7967-7970.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalNot applicablepeer-review