Ultra-compliant thermal AFM probes for studying of cellular properties

King Wai Chiu Lai; Angelo Gaitas; Ruiguo Yang; Carmen Kar Man Fung; Ning Xi

doi:10.1109/NANO.2010.5697767

Ultra-compliant thermal AFM probes for studying of cellular properties

King Wai Chiu Lai^*
, Angelo Gaitas
, Ruiguo Yang
, Carmen Kar Man Fung
, Ning Xi

^*Corresponding author for this work

Research output: Chapters, Conference Papers, Creative and Literary Works › RGC 32 - Refereed conference paper (with host publication) › peer-review

3 Citations (Scopus)

Abstract

Atomic force microscopy (AFM) can be used for a number of nanoscale biological studies. It opens the possibility to monitor cellular processes in physiological conditions with the ability to perform high resolution imaging and force measurements. However, analysis of the mechanical property of the living cells is difficult and the sensitivity is low. Conventional AFM probes use high-stiffness materials and therefore, it makes the force measurement on soft samples becoming more difficult. In this work an ultra-compliant AFM probe made of polyimide was used to provide an improved imaging and force measurement of cancer cells. The probe includes an embedded sensing element for thermal conductance characterization. The probe was used for thermal conductance and topographical mapping of biological cells. The probe allows for high speed imaging of cells in liquids. ©2010 IEEE.

Original language	English
Title of host publication	2010 10th IEEE Conference on Nanotechnology, NANO 2010
Pages	369-372
DOIs	https://doi.org/10.1109/NANO.2010.5697767
Publication status	Published - 2010
Externally published	Yes
Event	10th IEEE International Conference on Nanotechnology (NANO 2010) - Ilsan, Gyeonggi-Do, Korea, Republic of Duration: 17 Aug 2010 → 20 Aug 2010

Conference

Conference	10th IEEE International Conference on Nanotechnology (NANO 2010)
Place	Korea, Republic of
City	Ilsan, Gyeonggi-Do
Period	17/08/10 → 20/08/10

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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@inproceedings{308235e7ce054d3d9d5d675642378ee4,

title = "Ultra-compliant thermal AFM probes for studying of cellular properties",

abstract = "Atomic force microscopy (AFM) can be used for a number of nanoscale biological studies. It opens the possibility to monitor cellular processes in physiological conditions with the ability to perform high resolution imaging and force measurements. However, analysis of the mechanical property of the living cells is difficult and the sensitivity is low. Conventional AFM probes use high-stiffness materials and therefore, it makes the force measurement on soft samples becoming more difficult. In this work an ultra-compliant AFM probe made of polyimide was used to provide an improved imaging and force measurement of cancer cells. The probe includes an embedded sensing element for thermal conductance characterization. The probe was used for thermal conductance and topographical mapping of biological cells. The probe allows for high speed imaging of cells in liquids. {\textcopyright}2010 IEEE.",

author = "Lai, \{King Wai Chiu\} and Angelo Gaitas and Ruiguo Yang and Fung, \{Carmen Kar Man\} and Ning Xi",

year = "2010",

doi = "10.1109/NANO.2010.5697767",

language = "English",

isbn = "9781424470334",

pages = "369--372",

booktitle = "2010 10th IEEE Conference on Nanotechnology, NANO 2010",

note = "10th IEEE International Conference on Nanotechnology (NANO 2010) ; Conference date: 17-08-2010 Through 20-08-2010",

}

TY - GEN

T1 - Ultra-compliant thermal AFM probes for studying of cellular properties

AU - Lai, King Wai Chiu

AU - Gaitas, Angelo

AU - Yang, Ruiguo

AU - Fung, Carmen Kar Man

AU - Xi, Ning

PY - 2010

Y1 - 2010

N2 - Atomic force microscopy (AFM) can be used for a number of nanoscale biological studies. It opens the possibility to monitor cellular processes in physiological conditions with the ability to perform high resolution imaging and force measurements. However, analysis of the mechanical property of the living cells is difficult and the sensitivity is low. Conventional AFM probes use high-stiffness materials and therefore, it makes the force measurement on soft samples becoming more difficult. In this work an ultra-compliant AFM probe made of polyimide was used to provide an improved imaging and force measurement of cancer cells. The probe includes an embedded sensing element for thermal conductance characterization. The probe was used for thermal conductance and topographical mapping of biological cells. The probe allows for high speed imaging of cells in liquids. ©2010 IEEE.

AB - Atomic force microscopy (AFM) can be used for a number of nanoscale biological studies. It opens the possibility to monitor cellular processes in physiological conditions with the ability to perform high resolution imaging and force measurements. However, analysis of the mechanical property of the living cells is difficult and the sensitivity is low. Conventional AFM probes use high-stiffness materials and therefore, it makes the force measurement on soft samples becoming more difficult. In this work an ultra-compliant AFM probe made of polyimide was used to provide an improved imaging and force measurement of cancer cells. The probe includes an embedded sensing element for thermal conductance characterization. The probe was used for thermal conductance and topographical mapping of biological cells. The probe allows for high speed imaging of cells in liquids. ©2010 IEEE.

UR - https://www.scopus.com/pages/publications/79951846724

UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-79951846724&origin=recordpage

U2 - 10.1109/NANO.2010.5697767

DO - 10.1109/NANO.2010.5697767

M3 - RGC 32 - Refereed conference paper (with host publication)

SN - 9781424470334

SP - 369

EP - 372

BT - 2010 10th IEEE Conference on Nanotechnology, NANO 2010

T2 - 10th IEEE International Conference on Nanotechnology (NANO 2010)

Y2 - 17 August 2010 through 20 August 2010

ER -

Ultra-compliant thermal AFM probes for studying of cellular properties

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