Type II collagen scaffolds for tissue engineering

Xu Hu; Zhonglian Wu; Zhen Zhang; Hang Yao; Dong-An Wang

doi:10.1038/s43246-024-00598-x

Type II collagen scaffolds for tissue engineering

Xu Hu
, Zhonglian Wu
, Zhen Zhang
, Hang Yao^*
, Dong-An Wang^*

^*Corresponding author for this work

Department of Biomedical Engineering

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

33 Citations (Scopus)

28 Downloads (CityUHK Scholars)

Abstract

Type II collagen (CII), a key component of cartilaginous tissues, offers an attractive option for fabricating biomimetic scaffolds that provide mechanical support and biochemical signals to facilitate cell adhesion, proliferation, and differentiation. Advances in fabrication technologies have enabled the creation of intricate and multicellular CII-based scaffolds that more accurately replicate the natural structure of tissues. Here, we review the application of CII in tissue engineering and highlight its crucial contributions to the regeneration of hyaline cartilage and intervertebral discs. Additionally, we discuss the versatile roles of CII in other biomedical applications, including disease modeling, bone regeneration, and the development of artificial immune organs. © The Author(s) 2024.

Original language	English
Article number	149
Journal	Communications Materials
Volume	5
Online published	10 Aug 2024
DOIs	https://doi.org/10.1038/s43246-024-00598-x
Publication status	Published - 2024

Funding

This work was supported by Grant from Health@InnoHK: CNRM, Innovation and Technology Commission, Hong Kong SAR; Grants from City University of Hong Kong (9609335, 7006079, 7005949); Grant from Karolinska Institutet Ming Wai Lau Centre of Reparative Medicine (CityU 9231486); and Young Scientists Lifting Project of Jiangsu Province, China (TJ-2022-072).

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This full text is made available under CC-BY 4.0. https://creativecommons.org/licenses/by/4.0/

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AU - Hu, Xu

AU - Wu, Zhonglian

AU - Zhang, Zhen

AU - Yao, Hang

AU - Wang, Dong-An

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AB - Type II collagen (CII), a key component of cartilaginous tissues, offers an attractive option for fabricating biomimetic scaffolds that provide mechanical support and biochemical signals to facilitate cell adhesion, proliferation, and differentiation. Advances in fabrication technologies have enabled the creation of intricate and multicellular CII-based scaffolds that more accurately replicate the natural structure of tissues. Here, we review the application of CII in tissue engineering and highlight its crucial contributions to the regeneration of hyaline cartilage and intervertebral discs. Additionally, we discuss the versatile roles of CII in other biomedical applications, including disease modeling, bone regeneration, and the development of artificial immune organs. © The Author(s) 2024.

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DO - 10.1038/s43246-024-00598-x

M3 - RGC 21 - Publication in refereed journal

SN - 2662-4443

VL - 5

JO - Communications Materials

JF - Communications Materials

M1 - 149

ER -

Type II collagen scaffolds for tissue engineering

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ASDC_Sub: Futian Research Project: Development of Targeted Tumor-Mimicking Nanoparticles for Chemotherapeutic Drug Delivery and Modulation of the Glioblastoma Immune Microenvironment

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Type II collagen scaffolds for tissue engineering

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ASDC_Sub: Futian Research Project: Development of Targeted Tumor-Mimicking Nanoparticles for Chemotherapeutic Drug Delivery and Modulation of the Glioblastoma Immune Microenvironment

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