Two-step proximal gradient descent algorithm for photoacoustic signal unmixing
Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review
Author(s)
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Detail(s)
Original language | English |
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Article number | 100379 |
Journal / Publication | Photoacoustics |
Volume | 27 |
Online published | 9 Jun 2022 |
Publication status | Published - Sept 2022 |
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DOI | DOI |
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Attachment(s) | Documents
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Link to Scopus | https://www.scopus.com/record/display.uri?eid=2-s2.0-85131918265&origin=recordpage |
Permanent Link | https://scholars.cityu.edu.hk/en/publications/publication(17d2de19-e051-483a-ad95-55bd407e6d17).html |
Abstract
Photoacoustic microscopy uses multiple wavelengths to measure concentrations of different absorbers. The speed of sound limits the shortest wavelength switching time to sub-microseconds, which is a bottleneck for high-speed broad-spectrum imaging. Via computational separation of overlapped signals, we can break the sound-speed limit on the wavelength switching time. This paper presents a new signal unmixing algorithm named two-step proximal gradient descent. It is advantageous in separating multiple wavelengths with long overlapping and high noise. In the simulation, we can unmix up to nine overlapped signals and successfully separate three overlapped signals with 12-ns delay and 15.9-dB signal-to-noise ratio. We apply this technique to separate three wavelength photoacoustic images in microvessels. In vivo results show that the algorithm can successfully unmix overlapped multi-wavelength photoacoustic signals, and the unmixed data can improve accuracy in oxygen saturation imaging.
Research Area(s)
- Signal separation, Fast multi-wavelength excitation, Oxygen saturation, Functional photoacoustic imaging, MICROSCOPY, RESOLUTION, LASER
Citation Format(s)
Two-step proximal gradient descent algorithm for photoacoustic signal unmixing. / Qu, Zheng; Liu, Chao; Zhu, Jingyi et al.
In: Photoacoustics, Vol. 27, 100379, 09.2022.
In: Photoacoustics, Vol. 27, 100379, 09.2022.
Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review
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