Two-Layer Scaffold Platforms for Drug Screening of Nasopharyngeal Epithelial Cells

Research output: Chapters, Conference Papers, Creative and Literary Works (RGC: 12, 32, 41, 45)32_Refereed conference paper (with ISBN/ISSN)peer-review

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Author(s)

Detail(s)

Original languageEnglish
Title of host publication33rd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2020
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages412-415
ISBN (Electronic)9781728135809
ISBN (Print)9781728135823
Publication statusPublished - Jan 2020

Publication series

NameProceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
Volume2020-January
ISSN (Print)1084-6999
ISSN (Electronic)2160-1968

Conference

Title33rd IEEE International Conference on Micro Electro Mechanical Systems (MEMS 2020)
PlaceCanada
CityVancouver
Period18 - 22 January 2020

Abstract

A two-layer scaffold platform was designed for drug screening without using fluorescence staining to examine the effectiveness of the tested compounds. Nasopharyngeal epithelial (NP460) cells were used in this work. Typically, NP460 cells could not squeeze into the 10 μm narrow trenches but preferred to migrate on the top ridges. However, NP460 cells could migrate into 10 μm wide trenches after being stimulated by transforming growth factor beta-1 (TGF-β1) as the cells became more active. This double-layer scaffold platform served as a drug screening device by tracking the number of cells migrated into narrow trenches after drug treatment to test and monitor the effectiveness of a compound in a biomimetic microenvironment.

Research Area(s)

  • 3D Scaffold Platform, Cell Migration, Drug Screening, Biomimetic, NP460 Cells

Citation Format(s)

Two-Layer Scaffold Platforms for Drug Screening of Nasopharyngeal Epithelial Cells. / Lam, Bowie P.; Cheung, Ka Chi Sarah; Lam, Yun Wah; Pang, Stella W.

33rd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2020. Institute of Electrical and Electronics Engineers Inc., 2020. p. 412-415 9056387 (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS); Vol. 2020-January).

Research output: Chapters, Conference Papers, Creative and Literary Works (RGC: 12, 32, 41, 45)32_Refereed conference paper (with ISBN/ISSN)peer-review