Two metabolites with DNA-binding affinity from the mangrove fungus Xylaria sp. (#2508) from the South China Sea coast

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Zhigang She
  • L. L P Vrijmoed
  • E. B. Gareth Jones
  • Yongcheng Lin

Detail(s)

Original languageEnglish
Pages (from-to)365-368
Journal / PublicationChinese Journal of Chemistry
Volume27
Issue number2
Publication statusPublished - Feb 2009

Abstract

A novel metabolite xylopyridine A (1), together with a known compound pyrocoll (2), was isolated from mangrove endophytic fungus Xylaria sp. (#2508) collected from the South China Sea coast. Their structures were established on the basis of spectroscopic analysis, especially 2D-NMR. Their affinities toward calf thymus (CT) DNA were studied by fluorescence quenching and spectrophotometric titration experiments. The results indicate that 1 showes strong DNA-binding affinity presumably via an intercalation mechanism, thus it is exploitable as strong DNA-binders. © 2009 SIOC, CAS, Shanghai, & WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Research Area(s)

  • CT DNA-binding, Fluorescence, Fungus, Isolation, Metabolite, Xylopyridine A

Citation Format(s)

Two metabolites with DNA-binding affinity from the mangrove fungus Xylaria sp. (#2508) from the South China Sea coast. / Xu, Fang; Pang, Jiyan; Lu, Bingtai; Wang, Jiajun; Zhang, Yi; She, Zhigang; Vrijmoed, L. L P; Gareth Jones, E. B.; Lin, Yongcheng.

In: Chinese Journal of Chemistry, Vol. 27, No. 2, 02.2009, p. 365-368.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review