Two metabolites with DNA-binding affinity from the mangrove fungus Xylaria sp. (#2508) from the South China Sea coast

Fang Xu; Jiyan Pang; Bingtai Lu; Jiajun Wang; Yi Zhang; Zhigang She; L. L P Vrijmoed; E. B. Gareth Jones; Yongcheng Lin

doi:10.1002/cjoc.200990059

Author(s)

Fang Xu
Jiyan Pang
Bingtai Lu
Jiajun Wang
Yi Zhang
And 4 others

Zhigang She
L. L P Vrijmoed
E. B. Gareth Jones
Yongcheng Lin

Detail(s)

Original language	English
Pages (from-to)	365-368
Journal / Publication	Chinese Journal of Chemistry
Volume	27
Issue number	2
Publication status	Published - Feb 2009

Link(s)

DOI	DOI https://doi.org/10.1002/cjoc.200990059 Final Published version
	Check@CityULib
Link to Scopus	https://www.scopus.com/record/display.uri?eid=2-s2.0-67449161994&origin=recordpage
Permanent Link	https://scholars.cityu.edu.hk/en/publications/publication(7bb1f3a2-3f5e-42da-8e55-f0954c229325).html

Abstract

A novel metabolite xylopyridine A (1), together with a known compound pyrocoll (2), was isolated from mangrove endophytic fungus Xylaria sp. (#2508) collected from the South China Sea coast. Their structures were established on the basis of spectroscopic analysis, especially 2D-NMR. Their affinities toward calf thymus (CT) DNA were studied by fluorescence quenching and spectrophotometric titration experiments. The results indicate that 1 showes strong DNA-binding affinity presumably via an intercalation mechanism, thus it is exploitable as strong DNA-binders. © 2009 SIOC, CAS, Shanghai, & WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Research Area(s)

CT DNA-binding, Fluorescence, Fungus, Isolation, Metabolite, Xylopyridine A

Citation Format(s)

[ RIS ] [ BibTeX ]

Two metabolites with DNA-binding affinity from the mangrove fungus Xylaria sp. (#2508) from the South China Sea coast. / Xu, Fang; Pang, Jiyan; Lu, Bingtai et al.
In: Chinese Journal of Chemistry, Vol. 27, No. 2, 02.2009, p. 365-368.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

Xu, F, Pang, J, Lu, B, Wang, J, Zhang, Y, She, Z, Vrijmoed, LLP, Gareth Jones, EB & Lin, Y 2009, 'Two metabolites with DNA-binding affinity from the mangrove fungus Xylaria sp. (#2508) from the South China Sea coast', Chinese Journal of Chemistry, vol. 27, no. 2, pp. 365-368. https://doi.org/10.1002/cjoc.200990059

Xu, F., Pang, J., Lu, B., Wang, J., Zhang, Y., She, Z., Vrijmoed, L. L. P., Gareth Jones, E. B., & Lin, Y. (2009). Two metabolites with DNA-binding affinity from the mangrove fungus Xylaria sp. (#2508) from the South China Sea coast. Chinese Journal of Chemistry, 27(2), 365-368. https://doi.org/10.1002/cjoc.200990059

Xu F, Pang J, Lu B, Wang J, Zhang Y, She Z et al. Two metabolites with DNA-binding affinity from the mangrove fungus Xylaria sp. (#2508) from the South China Sea coast. Chinese Journal of Chemistry. 2009 Feb;27(2):365-368. doi: 10.1002/cjoc.200990059

Xu, Fang ; Pang, Jiyan ; Lu, Bingtai et al. / Two metabolites with DNA-binding affinity from the mangrove fungus Xylaria sp. (#2508) from the South China Sea coast. In: Chinese Journal of Chemistry. 2009 ; Vol. 27, No. 2. pp. 365-368.