Two-dimensional surface plasmon resonance biosensor array based on phase-sensitive measurement

H. P. Ho; K. S. Chan; C. L. Wong; K. F. Lei; W. I. Li; W. C. Law; S. Y. Wu; S. K. Kong; C. Lin

doi:10.1117/12.619180

Two-dimensional surface plasmon resonance biosensor array based on phase-sensitive measurement

H. P. Ho
, K. S. Chan
, C. L. Wong
, K. F. Lei
, W. I. Li
, W. C. Law
, S. Y. Wu
, S. K. Kong
, C. Lin

Research output: Journal Publications and Reviews › RGC 22 - Publication in policy or professional journal

4 Citations (Scopus)

Abstract

We report a 2-dimensional surface plasmon resonance (SPR) imaging array sensor based on differential phase measurement between p- and s-polarization. This parallel detection provides the advantage of high-throughput sensing, which is essential in recent biosensing technology. In the differential measurement approach, the signal (p) and reference (s) beams go through exactly identical optical path. This greatly improves the phase detection stability. In the present setup we use a low-cost imaging device and a simple data analysis program to perform the required arrayed sensing operation. The system demonstrates a refractive index resolution of 1×10^-4 RIU per degree phase change.

Original language	English
Article number	59270E
Pages (from-to)	1-10
Journal	Proceedings of SPIE - The International Society for Optical Engineering
Volume	5927
DOIs	https://doi.org/10.1117/12.619180
Publication status	Published - 2005
Event	Plasmonics: Metallic Nanostructures and Their Optical Properties III - San Diego, CA, United States Duration: 31 Jul 2005 → 3 Aug 2005

Research Keywords

Biosensors
Imaging
Interference
Surface plasmon resonance

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title = "Two-dimensional surface plasmon resonance biosensor array based on phase-sensitive measurement",

abstract = "We report a 2-dimensional surface plasmon resonance (SPR) imaging array sensor based on differential phase measurement between p- and s-polarization. This parallel detection provides the advantage of high-throughput sensing, which is essential in recent biosensing technology. In the differential measurement approach, the signal (p) and reference (s) beams go through exactly identical optical path. This greatly improves the phase detection stability. In the present setup we use a low-cost imaging device and a simple data analysis program to perform the required arrayed sensing operation. The system demonstrates a refractive index resolution of 1×10-4 RIU per degree phase change.",

keywords = "Biosensors, Imaging, Interference, Surface plasmon resonance",

author = "Ho, \{H. P.\} and Chan, \{K. S.\} and Wong, \{C. L.\} and Lei, \{K. F.\} and Li, \{W. I.\} and Law, \{W. C.\} and Wu, \{S. Y.\} and Kong, \{S. K.\} and C. Lin",

year = "2005",

doi = "10.1117/12.619180",

language = "English",

volume = "5927",

pages = "1--10",

journal = "Proceedings of SPIE - The International Society for Optical Engineering",

issn = "0277-786X",

publisher = "SPIE - International Society for Optical Engineering",

note = "Plasmonics: Metallic Nanostructures and Their Optical Properties III ; Conference date: 31-07-2005 Through 03-08-2005",

}

TY - JOUR

T1 - Two-dimensional surface plasmon resonance biosensor array based on phase-sensitive measurement

AU - Ho, H. P.

AU - Chan, K. S.

AU - Wong, C. L.

AU - Lei, K. F.

AU - Li, W. I.

AU - Law, W. C.

AU - Wu, S. Y.

AU - Kong, S. K.

AU - Lin, C.

PY - 2005

Y1 - 2005

N2 - We report a 2-dimensional surface plasmon resonance (SPR) imaging array sensor based on differential phase measurement between p- and s-polarization. This parallel detection provides the advantage of high-throughput sensing, which is essential in recent biosensing technology. In the differential measurement approach, the signal (p) and reference (s) beams go through exactly identical optical path. This greatly improves the phase detection stability. In the present setup we use a low-cost imaging device and a simple data analysis program to perform the required arrayed sensing operation. The system demonstrates a refractive index resolution of 1×10-4 RIU per degree phase change.

AB - We report a 2-dimensional surface plasmon resonance (SPR) imaging array sensor based on differential phase measurement between p- and s-polarization. This parallel detection provides the advantage of high-throughput sensing, which is essential in recent biosensing technology. In the differential measurement approach, the signal (p) and reference (s) beams go through exactly identical optical path. This greatly improves the phase detection stability. In the present setup we use a low-cost imaging device and a simple data analysis program to perform the required arrayed sensing operation. The system demonstrates a refractive index resolution of 1×10-4 RIU per degree phase change.

KW - Biosensors

KW - Imaging

KW - Interference

KW - Surface plasmon resonance

UR - https://www.scopus.com/pages/publications/31844445420

UR - https://www.scopus.com/pages/publications/31844445420#tab=impact

U2 - 10.1117/12.619180

DO - 10.1117/12.619180

M3 - RGC 22 - Publication in policy or professional journal

SN - 0277-786X

VL - 5927

SP - 1

EP - 10

JO - Proceedings of SPIE - The International Society for Optical Engineering

JF - Proceedings of SPIE - The International Society for Optical Engineering

M1 - 59270E

T2 - Plasmonics: Metallic Nanostructures and Their Optical Properties III

Y2 - 31 July 2005 through 3 August 2005

ER -

Two-dimensional surface plasmon resonance biosensor array based on phase-sensitive measurement

Abstract

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