Two dimensional nanosheets as immunoregulator improve HIV vaccine efficacy

Ye Liu; Yekkuni L. Balachandran; Zulan Li; Yulong Cong; Yiming Shao; Xingyu Jiang

doi:10.1039/d1sc04044h

Two dimensional nanosheets as immunoregulator improve HIV vaccine efficacy

Ye Liu^*, Yekkuni L. Balachandran, Zulan Li, Yulong Cong, Yiming Shao, Xingyu Jiang^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

7 Citations (Scopus)

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Abstract

Two-dimensional (2D) nanosheets as carriers have shown promising potential for surface-displaying or loading various drugs. Nevertheless, developing sheet-like materials themselves into an immunoregulator has never been realized so far. In this study, we take advantage of the immunoregulatory effects of rare earth elements themselves and develop water-soluble erbium-dysprosium 2D nanosheets (2D NSs). Such 2D NSs can target lymph nodes and activate macrophages to improve vaccine efficacy in mice significantly. Transcriptome analysis further reveals that six critical molecules (Msr1, Ccr2, Serpinb9, Klrk1, Klrd1, Klrc1) closely correlate with 2D NS-mediated immunoregulation in vivo. For the first time, the present work realizes a proof-of-concept for designing immunoregulatory 2D NSs and shows a promising potential of 2D NSs for improving the immunoprophylaxis/immunotherapy of vaccines. © The Royal Society of Chemistry 2021.

Original language	English
Pages (from-to)	178-187
Journal	Chemical Science
Volume	13
Issue number	1
Online published	7 Dec 2021
DOIs	https://doi.org/10.1039/d1sc04044h
Publication status	Published - 7 Jan 2022
Externally published	Yes

Funding

We thank financial supports from the National Natural Science Foundation of China (21874033, 21535001, 81730051, 21761142006, 81501790), the National Key R&D Program of China (2018YFA0902600, 2017YFA0205901), the Chinese Academy of Sciences (QYZDJ-SSW-SLH039, 121D11KYSB20170026, XDA16020902), Tencent Foundation through the XPLORER PRIZE, the Leading Medical Talents Program of Health Commission of Yunnan Province (L-2018013), the Young and Middle-Aged Academic and Technical Leaders Program of Yunnan Province (202005AC160010), the Basic Research Program of Yunnan Province (202101AS070051), Shenzhen Key Laboratory of Smart Healthcare Engineering (ZDSYS20200811144003009).

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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This full text is made available under CC-BY 3.0. https://creativecommons.org/licenses/by/3.0/

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title = "Two dimensional nanosheets as immunoregulator improve HIV vaccine efficacy",

abstract = "Two-dimensional (2D) nanosheets as carriers have shown promising potential for surface-displaying or loading various drugs. Nevertheless, developing sheet-like materials themselves into an immunoregulator has never been realized so far. In this study, we take advantage of the immunoregulatory effects of rare earth elements themselves and develop water-soluble erbium-dysprosium 2D nanosheets (2D NSs). Such 2D NSs can target lymph nodes and activate macrophages to improve vaccine efficacy in mice significantly. Transcriptome analysis further reveals that six critical molecules (Msr1, Ccr2, Serpinb9, Klrk1, Klrd1, Klrc1) closely correlate with 2D NS-mediated immunoregulation in vivo. For the first time, the present work realizes a proof-of-concept for designing immunoregulatory 2D NSs and shows a promising potential of 2D NSs for improving the immunoprophylaxis/immunotherapy of vaccines. {\textcopyright} The Royal Society of Chemistry 2021.",

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AU - Liu, Ye

AU - Balachandran, Yekkuni L.

AU - Li, Zulan

AU - Cong, Yulong

AU - Shao, Yiming

AU - Jiang, Xingyu

PY - 2022/1/7

Y1 - 2022/1/7

N2 - Two-dimensional (2D) nanosheets as carriers have shown promising potential for surface-displaying or loading various drugs. Nevertheless, developing sheet-like materials themselves into an immunoregulator has never been realized so far. In this study, we take advantage of the immunoregulatory effects of rare earth elements themselves and develop water-soluble erbium-dysprosium 2D nanosheets (2D NSs). Such 2D NSs can target lymph nodes and activate macrophages to improve vaccine efficacy in mice significantly. Transcriptome analysis further reveals that six critical molecules (Msr1, Ccr2, Serpinb9, Klrk1, Klrd1, Klrc1) closely correlate with 2D NS-mediated immunoregulation in vivo. For the first time, the present work realizes a proof-of-concept for designing immunoregulatory 2D NSs and shows a promising potential of 2D NSs for improving the immunoprophylaxis/immunotherapy of vaccines. © The Royal Society of Chemistry 2021.

AB - Two-dimensional (2D) nanosheets as carriers have shown promising potential for surface-displaying or loading various drugs. Nevertheless, developing sheet-like materials themselves into an immunoregulator has never been realized so far. In this study, we take advantage of the immunoregulatory effects of rare earth elements themselves and develop water-soluble erbium-dysprosium 2D nanosheets (2D NSs). Such 2D NSs can target lymph nodes and activate macrophages to improve vaccine efficacy in mice significantly. Transcriptome analysis further reveals that six critical molecules (Msr1, Ccr2, Serpinb9, Klrk1, Klrd1, Klrc1) closely correlate with 2D NS-mediated immunoregulation in vivo. For the first time, the present work realizes a proof-of-concept for designing immunoregulatory 2D NSs and shows a promising potential of 2D NSs for improving the immunoprophylaxis/immunotherapy of vaccines. © The Royal Society of Chemistry 2021.

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DO - 10.1039/d1sc04044h

M3 - RGC 21 - Publication in refereed journal

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JO - Chemical Science

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Two dimensional nanosheets as immunoregulator improve HIV vaccine efficacy

Abstract

Funding

UN SDGs

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