Two dimensional nanosheets as immunoregulator improve HIV vaccine efficacy

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

4 Scopus Citations
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Author(s)

  • Ye Liu
  • Zulan Li
  • Yulong Cong
  • Yiming Shao
  • Xingyu Jiang

Detail(s)

Original languageEnglish
Pages (from-to)178-187
Journal / PublicationChemical Science
Volume13
Issue number1
Online published7 Dec 2021
Publication statusPublished - 7 Jan 2022
Externally publishedYes

Link(s)

Abstract

Two-dimensional (2D) nanosheets as carriers have shown promising potential for surface-displaying or loading various drugs. Nevertheless, developing sheet-like materials themselves into an immunoregulator has never been realized so far. In this study, we take advantage of the immunoregulatory effects of rare earth elements themselves and develop water-soluble erbium-dysprosium 2D nanosheets (2D NSs). Such 2D NSs can target lymph nodes and activate macrophages to improve vaccine efficacy in mice significantly. Transcriptome analysis further reveals that six critical molecules (Msr1, Ccr2, Serpinb9, Klrk1, Klrd1, Klrc1) closely correlate with 2D NS-mediated immunoregulation in vivo. For the first time, the present work realizes a proof-of-concept for designing immunoregulatory 2D NSs and shows a promising potential of 2D NSs for improving the immunoprophylaxis/immunotherapy of vaccines. © The Royal Society of Chemistry 2021.

Research Area(s)

Citation Format(s)

Two dimensional nanosheets as immunoregulator improve HIV vaccine efficacy. / Liu, Ye; Balachandran, Yekkuni L.; Li, Zulan et al.
In: Chemical Science, Vol. 13, No. 1, 07.01.2022, p. 178-187.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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