Tuning Near-Infrared-to-Ultraviolet Upconversion in Lanthanide-Doped Nanoparticles for Biomedical Applications

Han-Lin Wei; Weilin Zheng; Xin Zhang; Hao Suo; Bing Chen; Yanze Wang; Feng Wang

doi:10.1002/adom.202201716

Tuning Near-Infrared-to-Ultraviolet Upconversion in Lanthanide-Doped Nanoparticles for Biomedical Applications

Han-Lin Wei, Weilin Zheng, Xin Zhang, Hao Suo, Bing Chen, Yanze Wang, Feng Wang^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

26 Citations (Scopus)

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Abstract

Ultraviolet (UV) radiation offers many exciting biomedical applications such as biosensing and cancer therapy. Photon upconversion through lanthanide (Ln)-doped nanoparticles is an attractive approach for UV generation by excitation of near-infrared (NIR) light, which is readily accessible and highly penetrating in tissue environments. By rationally engineering the emission property of upconversion nanoparticles (UCNPs) coupled with surface functionalization with photoactivatable molecules, various nanosystems can be constructed for biomedicine with the feature of minimal living tissue damage and remote light delivery at high spatiotemporal precisions. Such technology facilitates sensitive diagnosis and effective treatment of various diseases. This review focuses on the recent development of NIR-to-UV UCNPs, simultaneously highlighting emergent biomedical applications enabled by these materials. © 2022 Wiley-VCH GmbH.

Original language	English
Article number	2201716
Journal	Advanced Optical Materials
Volume	11
Issue number	11
Online published	25 Oct 2022
DOIs	https://doi.org/10.1002/adom.202201716
Publication status	Published - 5 Jun 2023

Funding

This work was supported by the Research Grants Council of Hong Kong (Nos. 11205219 and C5110-20G) and the National Natural Science Foundation of China (No. 21773200).

Research Keywords

cancer therapy
medical diagnosis
near-infrared excitation
photon upconversion
ultraviolet emission

Publisher's Copyright Statement

COPYRIGHT TERMS OF DEPOSITED POSTPRINT FILE: This is the peer reviewed version of the following article: Wei, H-L., Zheng, W., Zhang, X., Suo, H., Chen, B., Wang, Y., & Wang, F. (2022). Tuning Near-Infrared-to-Ultraviolet Upconversion in Lanthanide-Doped Nanoparticles for Biomedical Applications. Advanced Optical Materials, 11(11), [2201716]
which has been published in final form at https://doi.org/10.1002/adom.202201716. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.

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title = "Tuning Near-Infrared-to-Ultraviolet Upconversion in Lanthanide-Doped Nanoparticles for Biomedical Applications",

abstract = "Ultraviolet (UV) radiation offers many exciting biomedical applications such as biosensing and cancer therapy. Photon upconversion through lanthanide (Ln)-doped nanoparticles is an attractive approach for UV generation by excitation of near-infrared (NIR) light, which is readily accessible and highly penetrating in tissue environments. By rationally engineering the emission property of upconversion nanoparticles (UCNPs) coupled with surface functionalization with photoactivatable molecules, various nanosystems can be constructed for biomedicine with the feature of minimal living tissue damage and remote light delivery at high spatiotemporal precisions. Such technology facilitates sensitive diagnosis and effective treatment of various diseases. This review focuses on the recent development of NIR-to-UV UCNPs, simultaneously highlighting emergent biomedical applications enabled by these materials. {\textcopyright} 2022 Wiley-VCH GmbH.",

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author = "Han-Lin Wei and Weilin Zheng and Xin Zhang and Hao Suo and Bing Chen and Yanze Wang and Feng Wang",

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AU - Wei, Han-Lin

AU - Zheng, Weilin

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AU - Suo, Hao

AU - Chen, Bing

AU - Wang, Yanze

AU - Wang, Feng

PY - 2023/6/5

Y1 - 2023/6/5

N2 - Ultraviolet (UV) radiation offers many exciting biomedical applications such as biosensing and cancer therapy. Photon upconversion through lanthanide (Ln)-doped nanoparticles is an attractive approach for UV generation by excitation of near-infrared (NIR) light, which is readily accessible and highly penetrating in tissue environments. By rationally engineering the emission property of upconversion nanoparticles (UCNPs) coupled with surface functionalization with photoactivatable molecules, various nanosystems can be constructed for biomedicine with the feature of minimal living tissue damage and remote light delivery at high spatiotemporal precisions. Such technology facilitates sensitive diagnosis and effective treatment of various diseases. This review focuses on the recent development of NIR-to-UV UCNPs, simultaneously highlighting emergent biomedical applications enabled by these materials. © 2022 Wiley-VCH GmbH.

AB - Ultraviolet (UV) radiation offers many exciting biomedical applications such as biosensing and cancer therapy. Photon upconversion through lanthanide (Ln)-doped nanoparticles is an attractive approach for UV generation by excitation of near-infrared (NIR) light, which is readily accessible and highly penetrating in tissue environments. By rationally engineering the emission property of upconversion nanoparticles (UCNPs) coupled with surface functionalization with photoactivatable molecules, various nanosystems can be constructed for biomedicine with the feature of minimal living tissue damage and remote light delivery at high spatiotemporal precisions. Such technology facilitates sensitive diagnosis and effective treatment of various diseases. This review focuses on the recent development of NIR-to-UV UCNPs, simultaneously highlighting emergent biomedical applications enabled by these materials. © 2022 Wiley-VCH GmbH.

KW - cancer therapy

KW - medical diagnosis

KW - near-infrared excitation

KW - photon upconversion

KW - ultraviolet emission

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ER -

Tuning Near-Infrared-to-Ultraviolet Upconversion in Lanthanide-Doped Nanoparticles for Biomedical Applications

Abstract

Funding

Research Keywords

Publisher's Copyright Statement

UN SDGs

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CRF-ExtU-Lead: Multi-level Synergistic COVID-19 Point-of-care Diagnostics Based on Upconversion Luminescence Biosensing Platform

GRF: Constructing Deep Ultraviolet Microlasers through Photon Upconversion in Heavily-Doped Nanocrystals

Cite this

Tuning Near-Infrared-to-Ultraviolet Upconversion in Lanthanide-Doped Nanoparticles for Biomedical Applications

Abstract

Funding

Research Keywords

Publisher's Copyright Statement

UN SDGs

Access Output

Other Access Options

Permanent Link

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Projects

CRF-ExtU-Lead: Multi-level Synergistic COVID-19 Point-of-care Diagnostics Based on Upconversion Luminescence Biosensing Platform

GRF: Constructing Deep Ultraviolet Microlasers through Photon Upconversion in Heavily-Doped Nanocrystals

Cite this