Tuning Near-Infrared-to-Ultraviolet Upconversion in Lanthanide-Doped Nanoparticles for Biomedical Applications

Han-Lin Wei, Weilin Zheng, Xin Zhang, Hao Suo, Bing Chen, Yanze Wang, Feng Wang*

*Corresponding author for this work

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

26 Citations (Scopus)
88 Downloads (CityUHK Scholars)

Abstract

Ultraviolet (UV) radiation offers many exciting biomedical applications such as biosensing and cancer therapy. Photon upconversion through lanthanide (Ln)-doped nanoparticles is an attractive approach for UV generation by excitation of near-infrared (NIR) light, which is readily accessible and highly penetrating in tissue environments. By rationally engineering the emission property of upconversion nanoparticles (UCNPs) coupled with surface functionalization with photoactivatable molecules, various nanosystems can be constructed for biomedicine with the feature of minimal living tissue damage and remote light delivery at high spatiotemporal precisions. Such technology facilitates sensitive diagnosis and effective treatment of various diseases. This review focuses on the recent development of NIR-to-UV UCNPs, simultaneously highlighting emergent biomedical applications enabled by these materials. © 2022 Wiley-VCH GmbH.
Original languageEnglish
Article number2201716
JournalAdvanced Optical Materials
Volume11
Issue number11
Online published25 Oct 2022
DOIs
Publication statusPublished - 5 Jun 2023

Funding

This work was supported by the Research Grants Council of Hong Kong (Nos. 11205219 and C5110-20G) and the National Natural Science Foundation of China (No. 21773200).

Research Keywords

  • cancer therapy
  • medical diagnosis
  • near-infrared excitation
  • photon upconversion
  • ultraviolet emission

Publisher's Copyright Statement

  • COPYRIGHT TERMS OF DEPOSITED POSTPRINT FILE: This is the peer reviewed version of the following article: Wei, H-L., Zheng, W., Zhang, X., Suo, H., Chen, B., Wang, Y., & Wang, F. (2022). Tuning Near-Infrared-to-Ultraviolet Upconversion in Lanthanide-Doped Nanoparticles for Biomedical Applications. Advanced Optical Materials, 11(11), [2201716]
  • which has been published in final form at https://doi.org/10.1002/adom.202201716. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.

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