Abstract
Diabetic kidney disease (DKD) is a chronic complication of diabetes and the leading cause of end-stage renal disease (ESRD) worldwide. Currently, there are limited therapeutic drugs available for DKD. While previous research has primarily focused on glomerular injury, recent studies have increasingly emphasized the role of renal tubular injury in the pathogenesis of DKD. Various factors, including hyperglycemia, lipid accumulation, oxidative stress, hypoxia, RAAS, ER stress, inflammation, EMT and programmed cell death, have been shown to induce renal tubular injury and contribute to the progression of DKD. Additionally, traditional hypoglycemic drugs, anti-inflammation therapies, anti-senescence therapies, mineralocorticoid receptor antagonists, and stem cell therapies have demonstrated their potential to alleviate renal tubular injury in DKD. This review will provide insights into the latest research on the mechanisms and treatments of renal tubular injury in DKD. Copyright © 2023 Wang, Jin, Cheng and Li.
| Original language | English |
|---|---|
| Article number | 1238927 |
| Journal | Frontiers in Endocrinology |
| Volume | 14 |
| Online published | 2 Aug 2023 |
| DOIs | |
| Publication status | Published - 2023 |
Research Keywords
- diabetic kidney disease
- mechanism
- programmed cell death
- stem cell
- therapy
- tubular injury
Publisher's Copyright Statement
- This full text is made available under CC-BY 4.0. https://creativecommons.org/licenses/by/4.0/
