Trust as a mediator in the relationship between childhood sexual abuse and IL-6 level in adulthood

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

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Author(s)

  • Siu-Man Ng
  • Ling-Li Leng
  • Qian Wen Xie
  • Jessie S. M. Chan
  • Celia H. Y. Chan
  • Kwok Fai So
  • Ang Li
  • Kevin K. T. Po
  • L. P. Yuen
  • Kam-Shing Ku
  • Zoë Chouliara
  • Amos C. Y. Cheung
  • Cecilia L.W. Chan
  • Clifton Emery

Detail(s)

Original languageEnglish
Article numbere0232932
Journal / PublicationPLoS ONE
Volume15
Issue number5
Publication statusPublished - 15 May 2020

Link(s)

Abstract

Childhood sexual abuse (CSA) has been shown to predict the coupling of depression and inflammation in adulthood. Trust within intimate relationships, a core element in marital relations, has been shown to predict positive physical and mental health outcomes, but the mediating role of trust in partners in the association between CSA and inflammation in adulthood requires further study. The present study aimed to examine the impact of CSA on inflammatory biomarkers (IL-6 and IL-1β) in adults with depression and the mediating role of trust. A cross-sectional survey data set of adults presenting with mood and sleep disturbance was used in the analysis. CSA demonstrated a significant negative correlation with IL-6 level (r = -0.28, p<0. 01) in adults with clinically significant depression, while trust showed a significant positive correlation with IL-6 level (r = 0.36, p < .01). Sobel test and bootstrapping revealed a significant mediating role for trust between CSA and IL-6 level. CSA and trust in partners were revealed to have significant associations with IL-6 level in adulthood. Counterintuitively, the directions of association were not those expected. Trust played a mediating role between CSA and adulthood levels of IL-6. Plausible explanations for these counterintuitive findings are discussed.

Research Area(s)

Citation Format(s)

Trust as a mediator in the relationship between childhood sexual abuse and IL-6 level in adulthood. / Ng, Siu-Man; Leng, Ling-Li; Xie, Qian Wen; Chan, Jessie S. M.; Chan, Celia H. Y.; So, Kwok Fai; Li, Ang; Po, Kevin K. T.; Yuen, L. P.; Ku, Kam-Shing; Choi, Anna W. M.; Chouliara, Zoë; Cheung, Amos C. Y.; Chan, Cecilia L.W.; Emery, Clifton.

In: PLoS ONE, Vol. 15, No. 5, e0232932, 15.05.2020.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal