TRPC5 channels participate in pressure-sensing in aortic baroreceptors

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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Author(s)

  • On-Chai Lau
  • Bing Shen
  • Ching-On Wong
  • Yung-Wui Tjong
  • Chun-Yin Lo
  • Hui-Chuan Wang
  • Yang-Chao Chen
  • Man-Lung Fung
  • John Anthony Rudd
  • Xiaoqiang Yao

Detail(s)

Original languageEnglish
Article number11947
Journal / PublicationNature Communications
Volume7
Online published14 Jul 2016
Publication statusPublished - 2016
Externally publishedYes

Link(s)

Abstract

Blood pressure is maintained within a normal physiological range by a sophisticated regulatory mechanism. Baroreceptors serve as a frontline sensor to detect the change in blood pressure. Nerve signals are then sent to the cardiovascular control centre in the brain in order to stimulate baroreflex responses. Here, we identify TRPC5 channels as a mechanical sensor in aortic baroreceptors. In Trpc5 knockout mice, the pressure-induced action potential firings in the afferent nerve and the baroreflex-mediated heart rate reduction are attenuated. Telemetric measurements of blood pressure demonstrate that Trpc5 knockout mice display severe daily blood pressure fluctuation. Our results suggest that TRPC5 channels represent a key pressure transducer in the baroreceptors and play an important role in maintaining blood pressure stability. Because baroreceptor dysfunction contributes to a variety of cardiovascular diseases including hypertension, heart failure and myocardial infarction, our findings may have important future clinical implications.

Research Area(s)

Citation Format(s)

TRPC5 channels participate in pressure-sensing in aortic baroreceptors. / Lau, On-Chai; Shen, Bing; Wong, Ching-On et al.
In: Nature Communications, Vol. 7, 11947, 2016.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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