Tristetraprolin, a Potential Safeguard Against Carcinoma: Role in the Tumor Microenvironment

Diwen Zhang; Zhigang Zhou; Ruixia Yang; Sujun Zhang; Bin Zhang; Yanxuan Tan; Lingyao Chen; Tao Li; Jian Tu

doi:10.3389/fonc.2021.632189

Tristetraprolin, a Potential Safeguard Against Carcinoma: Role in the Tumor Microenvironment

Diwen Zhang
, Zhigang Zhou
, Ruixia Yang
, Sujun Zhang
, Bin Zhang
, Yanxuan Tan
, Lingyao Chen
, Tao Li^*
, Jian Tu^*

^*Corresponding author for this work

Department of Biomedical Sciences

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

12 Citations (Scopus)

53 Downloads (CityUHK Scholars)

Abstract

Tristetraprolin (TTP), a well-known RNA-binding protein, primarily affects the expression of inflammation-related proteins by binding to the targeted AU-rich element in the 3’ untranslated region after transcription and subsequently mediates messenger RNA decay. Recent studies have focused on the role of TTP in tumors and their related microenvironments, most of which have referred to TTP as a potential tumor suppressor involved in regulating cell proliferation, apoptosis, and metastasis of various cancers, as well as tumor immunity, inflammation, and metabolism of the microenvironment. Elevated TTP expression levels could aid the diagnosis and treatment of different cancers, improving the prognosis of patients. The aim of this review is to describe the role of TTP as a potential safeguard against carcinoma.

Original language	English
Article number	632189
Journal	Frontiers in Oncology
Volume	11
Online published	7 May 2021
DOIs	https://doi.org/10.3389/fonc.2021.632189
Publication status	Published - May 2021

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Keywords

carcinoma
potential safeguard
RNA binding protein
tristetraprolin (TTP)
tumor microenvironment (TME)

Publisher's Copyright Statement

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).

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10.3389/fonc.2021.632189

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title = "Tristetraprolin, a Potential Safeguard Against Carcinoma: Role in the Tumor Microenvironment",

abstract = "Tristetraprolin (TTP), a well-known RNA-binding protein, primarily affects the expression of inflammation-related proteins by binding to the targeted AU-rich element in the 3{\textquoteright} untranslated region after transcription and subsequently mediates messenger RNA decay. Recent studies have focused on the role of TTP in tumors and their related microenvironments, most of which have referred to TTP as a potential tumor suppressor involved in regulating cell proliferation, apoptosis, and metastasis of various cancers, as well as tumor immunity, inflammation, and metabolism of the microenvironment. Elevated TTP expression levels could aid the diagnosis and treatment of different cancers, improving the prognosis of patients. The aim of this review is to describe the role of TTP as a potential safeguard against carcinoma.",

keywords = "carcinoma, potential safeguard, RNA binding protein, tristetraprolin (TTP), tumor microenvironment (TME)",

author = "Diwen Zhang and Zhigang Zhou and Ruixia Yang and Sujun Zhang and Bin Zhang and Yanxuan Tan and Lingyao Chen and Tao Li and Jian Tu",

year = "2021",

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doi = "10.3389/fonc.2021.632189",

language = "English",

volume = "11",

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TY - JOUR

T1 - Tristetraprolin, a Potential Safeguard Against Carcinoma

T2 - Role in the Tumor Microenvironment

AU - Zhang, Diwen

AU - Zhou, Zhigang

AU - Yang, Ruixia

AU - Zhang, Sujun

AU - Zhang, Bin

AU - Tan, Yanxuan

AU - Chen, Lingyao

AU - Li, Tao

AU - Tu, Jian

PY - 2021/5

Y1 - 2021/5

N2 - Tristetraprolin (TTP), a well-known RNA-binding protein, primarily affects the expression of inflammation-related proteins by binding to the targeted AU-rich element in the 3’ untranslated region after transcription and subsequently mediates messenger RNA decay. Recent studies have focused on the role of TTP in tumors and their related microenvironments, most of which have referred to TTP as a potential tumor suppressor involved in regulating cell proliferation, apoptosis, and metastasis of various cancers, as well as tumor immunity, inflammation, and metabolism of the microenvironment. Elevated TTP expression levels could aid the diagnosis and treatment of different cancers, improving the prognosis of patients. The aim of this review is to describe the role of TTP as a potential safeguard against carcinoma.

AB - Tristetraprolin (TTP), a well-known RNA-binding protein, primarily affects the expression of inflammation-related proteins by binding to the targeted AU-rich element in the 3’ untranslated region after transcription and subsequently mediates messenger RNA decay. Recent studies have focused on the role of TTP in tumors and their related microenvironments, most of which have referred to TTP as a potential tumor suppressor involved in regulating cell proliferation, apoptosis, and metastasis of various cancers, as well as tumor immunity, inflammation, and metabolism of the microenvironment. Elevated TTP expression levels could aid the diagnosis and treatment of different cancers, improving the prognosis of patients. The aim of this review is to describe the role of TTP as a potential safeguard against carcinoma.

KW - carcinoma

KW - potential safeguard

KW - RNA binding protein

KW - tristetraprolin (TTP)

KW - tumor microenvironment (TME)

UR - https://www.scopus.com/pages/publications/85106146054

UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-85106146054&origin=recordpage

U2 - 10.3389/fonc.2021.632189

DO - 10.3389/fonc.2021.632189

M3 - RGC 21 - Publication in refereed journal

C2 - 34026612

SN - 2234-943X

VL - 11

JO - Frontiers in Oncology

JF - Frontiers in Oncology

M1 - 632189

ER -

Tristetraprolin, a Potential Safeguard Against Carcinoma: Role in the Tumor Microenvironment

Abstract

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Research Keywords

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