TRAVERSING BEHAVIOR OF NASOPHARYNGEAL EPITHELIAL AND CARCINOMA CELLS ON TWO-LAYER SCAFFOLD PLATFORMS

M. T. Wang; S. W. Pang

doi:10.1109/MEMS51782.2021.9375308

TRAVERSING BEHAVIOR OF NASOPHARYNGEAL EPITHELIAL AND CARCINOMA CELLS ON TWO-LAYER SCAFFOLD PLATFORMS

M. T. Wang
, S. W. Pang^*

^*Corresponding author for this work

Research output: Chapters, Conference Papers, Creative and Literary Works › RGC 32 - Refereed conference paper (with host publication) › peer-review

Abstract

In this work, two-layer scaffold platforms with different overlay angles and top layer thicknesses were designed to separate nasopharyngeal epithelial (NP460) cells from carcinoma (NPC43) cells. The scaffold platforms were used to mimic the extracellular matrix. The overlay angle between the top and bottom layers was varied from 30° to 90° and the top layer thickness was tuned from 5 to 30 μm. These designs provided different surface contact areas for cells to sense and attach when they migrated from the top layer to the bottom layer. The highest traversing probability was over 71% when the top layer was perpendicular to the bottom layer for NPC43 cells, but only 16% for NP460 cells. These platforms can be used for screening nasopharyngeal carcinoma cells in NPC tumor without expensive and complex procedures.

Original language	English
Title of host publication	The 34th IEEE International Conference on Micro Electro Mechanical Systems (MEMS2021)
Publisher	IEEE
Pages	513-516
ISBN (Electronic)	9781665419123
ISBN (Print)	9781665430241
DOIs	https://doi.org/10.1109/MEMS51782.2021.9375308
Publication status	Published - Jan 2021
Event	34th IEEE International Conference on Micro Electro Mechanical Systems (IEEE MEMS 2021) - Online, Gainesville, United States Duration: 25 Jan 2021 → 29 Jan 2021 https://www.mems21.org/

Publication series

Name
ISSN (Print)	1084-6999
ISSN (Electronic)	2160-1968

Conference

Conference	34th IEEE International Conference on Micro Electro Mechanical Systems (IEEE MEMS 2021)
Abbreviated title	MEMS 2021
Place	United States
City	Gainesville
Period	25/01/21 → 29/01/21
Internet address	https://www.mems21.org/

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Keywords

Two-layer Scaffold Platform
Traversing Behavior
Contact Area
NP460 Cell
NPC43 Cell

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10.1109/MEMS51782.2021.9375308

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Cite this

@inproceedings{5cd5e5d55d784b609240b9dc9c7e5b76,

title = "TRAVERSING BEHAVIOR OF NASOPHARYNGEAL EPITHELIAL AND CARCINOMA CELLS ON TWO-LAYER SCAFFOLD PLATFORMS",

abstract = "In this work, two-layer scaffold platforms with different overlay angles and top layer thicknesses were designed to separate nasopharyngeal epithelial (NP460) cells from carcinoma (NPC43) cells. The scaffold platforms were used to mimic the extracellular matrix. The overlay angle between the top and bottom layers was varied from 30° to 90° and the top layer thickness was tuned from 5 to 30 μm. These designs provided different surface contact areas for cells to sense and attach when they migrated from the top layer to the bottom layer. The highest traversing probability was over 71\% when the top layer was perpendicular to the bottom layer for NPC43 cells, but only 16\% for NP460 cells. These platforms can be used for screening nasopharyngeal carcinoma cells in NPC tumor without expensive and complex procedures.",

keywords = "Two-layer Scaffold Platform, Traversing Behavior, Contact Area, NP460 Cell, NPC43 Cell",

author = "Wang, \{M. T.\} and Pang, \{S. W.\}",

year = "2021",

month = jan,

doi = "10.1109/MEMS51782.2021.9375308",

language = "English",

isbn = "9781665430241",

publisher = "IEEE",

pages = "513--516",

booktitle = "The 34th IEEE International Conference on Micro Electro Mechanical Systems (MEMS2021)",

address = "United States",

note = "34th IEEE International Conference on Micro Electro Mechanical Systems (IEEE MEMS 2021), MEMS 2021 ; Conference date: 25-01-2021 Through 29-01-2021",

url = "https://www.mems21.org/",

}

Wang, MT & Pang, SW 2021, TRAVERSING BEHAVIOR OF NASOPHARYNGEAL EPITHELIAL AND CARCINOMA CELLS ON TWO-LAYER SCAFFOLD PLATFORMS. in The 34th IEEE International Conference on Micro Electro Mechanical Systems (MEMS2021)., 9375308, IEEE, pp. 513-516, 34th IEEE International Conference on Micro Electro Mechanical Systems (IEEE MEMS 2021), Gainesville, Florida, United States, 25/01/21. https://doi.org/10.1109/MEMS51782.2021.9375308

TRAVERSING BEHAVIOR OF NASOPHARYNGEAL EPITHELIAL AND CARCINOMA CELLS ON TWO-LAYER SCAFFOLD PLATFORMS. / Wang, M. T.; Pang, S. W.
The 34th IEEE International Conference on Micro Electro Mechanical Systems (MEMS2021). IEEE, 2021. p. 513-516 9375308.

Research output: Chapters, Conference Papers, Creative and Literary Works › RGC 32 - Refereed conference paper (with host publication) › peer-review

TY - GEN

T1 - TRAVERSING BEHAVIOR OF NASOPHARYNGEAL EPITHELIAL AND CARCINOMA CELLS ON TWO-LAYER SCAFFOLD PLATFORMS

AU - Wang, M. T.

AU - Pang, S. W.

PY - 2021/1

Y1 - 2021/1

N2 - In this work, two-layer scaffold platforms with different overlay angles and top layer thicknesses were designed to separate nasopharyngeal epithelial (NP460) cells from carcinoma (NPC43) cells. The scaffold platforms were used to mimic the extracellular matrix. The overlay angle between the top and bottom layers was varied from 30° to 90° and the top layer thickness was tuned from 5 to 30 μm. These designs provided different surface contact areas for cells to sense and attach when they migrated from the top layer to the bottom layer. The highest traversing probability was over 71% when the top layer was perpendicular to the bottom layer for NPC43 cells, but only 16% for NP460 cells. These platforms can be used for screening nasopharyngeal carcinoma cells in NPC tumor without expensive and complex procedures.

AB - In this work, two-layer scaffold platforms with different overlay angles and top layer thicknesses were designed to separate nasopharyngeal epithelial (NP460) cells from carcinoma (NPC43) cells. The scaffold platforms were used to mimic the extracellular matrix. The overlay angle between the top and bottom layers was varied from 30° to 90° and the top layer thickness was tuned from 5 to 30 μm. These designs provided different surface contact areas for cells to sense and attach when they migrated from the top layer to the bottom layer. The highest traversing probability was over 71% when the top layer was perpendicular to the bottom layer for NPC43 cells, but only 16% for NP460 cells. These platforms can be used for screening nasopharyngeal carcinoma cells in NPC tumor without expensive and complex procedures.

KW - Two-layer Scaffold Platform

KW - Traversing Behavior

KW - Contact Area

KW - NP460 Cell

KW - NPC43 Cell

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UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-85103445759&origin=recordpage

U2 - 10.1109/MEMS51782.2021.9375308

DO - 10.1109/MEMS51782.2021.9375308

M3 - RGC 32 - Refereed conference paper (with host publication)

SN - 9781665430241

SP - 513

EP - 516

BT - The 34th IEEE International Conference on Micro Electro Mechanical Systems (MEMS2021)

PB - IEEE

T2 - 34th IEEE International Conference on Micro Electro Mechanical Systems (IEEE MEMS 2021)

Y2 - 25 January 2021 through 29 January 2021

ER -

TRAVERSING BEHAVIOR OF NASOPHARYNGEAL EPITHELIAL AND CARCINOMA CELLS ON TWO-LAYER SCAFFOLD PLATFORMS

Abstract

Publication series

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UN SDGs

Research Keywords

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