TY - CHAP
T1 - Translocation Distance
T2 - Algorithms and Complexity
AU - Wang, Lusheng
PY - 2006
Y1 - 2006
N2 - With the development of fast sequencing techniques, large-scale DNA molecules are investigated with respect to the relative order of genes in them. Contrary to the traditional alignment approach, genome rearrangements are based on comparison of gene orders and the evolution of gene families. Genome rearrangement has become an important area in computational biology and bioinformatics. There are three basic operations, reversal, translocation, and transposition. Here we study the translocation operations. Multi-chromosomal genomes frequently evolve by translocation events that exchange genetic material between two chromosomes. We will discuss both signed and unsigned cases. © 2006 Elsevier Inc. All rights reserved.
AB - With the development of fast sequencing techniques, large-scale DNA molecules are investigated with respect to the relative order of genes in them. Contrary to the traditional alignment approach, genome rearrangements are based on comparison of gene orders and the evolution of gene families. Genome rearrangement has become an important area in computational biology and bioinformatics. There are three basic operations, reversal, translocation, and transposition. Here we study the translocation operations. Multi-chromosomal genomes frequently evolve by translocation events that exchange genetic material between two chromosomes. We will discuss both signed and unsigned cases. © 2006 Elsevier Inc. All rights reserved.
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UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-33750613046&origin=recordpage
U2 - 10.1016/S0065-2458(06)68003-0
DO - 10.1016/S0065-2458(06)68003-0
M3 - RGC 12 - Chapter in an edited book (Author)
SN - 0120121689
SN - 9780120121687
VL - 68
T3 - Advances in Computers
SP - 105
EP - 126
BT - Computational Biology and Bioinformatics
ER -