Transdermal delivery of small interfering RNAs with topically applied mesoporous silica nanoparticles for facile skin cancer treatment

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

17 Scopus Citations
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Author(s)

  • Daniel Chin Shiuan Lio
  • Chenghao Liu
  • Myo Myo Swe Oo
  • Christian Wiraja
  • Melissa Hui Yen Teo
  • Mengjia Zheng
  • Sharon Wan Ting Chew
  • Xiaomeng Wang

Detail(s)

Original languageEnglish
Pages (from-to)17041-17051
Journal / PublicationNanoscale
Volume11
Issue number36
Online published3 Sep 2019
Publication statusPublished - 28 Sep 2019
Externally publishedYes

Abstract

Small interfering RNA (siRNA) is a promising tool for the treatment of skin disorders including skin squamous cell carcinoma (SCC). This article develops a topical formulation for the transdermal delivery of siRNA. The formulation is built on mesoporous silica nanoparticles (MSNPs) with a loading capacity of 1.4 μg of oligonucleotide per mg of MSNPs. Cell experiments are employed to study the functionality of the formulation including the cellular uptake, the qualitative and quantitative detection of specific gene biomarkers. The clinical potential of this system is examined by topically delivering siRNA targeting TGFβR-1 (TGFβR-1) to the SCC in a mouse xenograft model. In comparison to the controls, MSNPs containing TGFβR-1 siRNA show a 2-fold suppression of TGFβR-1.

Citation Format(s)

Transdermal delivery of small interfering RNAs with topically applied mesoporous silica nanoparticles for facile skin cancer treatment. / Lio, Daniel Chin Shiuan; Liu, Chenghao; Oo, Myo Myo Swe; Wiraja, Christian; Teo, Melissa Hui Yen; Zheng, Mengjia; Chew, Sharon Wan Ting; Wang, Xiaomeng; Xu, Chenjie.

In: Nanoscale, Vol. 11, No. 36, 28.09.2019, p. 17041-17051.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review